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Both mind bomb (mib) and mind bomb-2 (mib2) encode RING E3 ubiquitin ligases that promote Delta ubiquitylation and endocytosis in Notch activation. Detailed morphological and molecular examinations revealed that zebrafish mib(ta52b) (missense mutation in the C-terminal RING Finger (RF), M1013R) and mib(m132) (nonsense mutation resulting in a truncated(More)
Notch signaling pathway defines an evolutionarily conserved mechanism in cell-fate determination in a broad spectrum of developmental processes through local cell interactions. mind bomb (mib) encodes an E3 ubiquitin ligase that is involved in Notch activation through Delta ubiquitylation and internalization. To further dissect the function of Mib, two(More)
It was already known that both mind bomb (mib) and mind bomb-2 (mib2) encode E3 ubiquitin ligases that target Delta in Notch activation. Here we further demonstrated that zebrafish Mib and Mib2, similar to their mouse orthologs, have a C-terminal-most RING finger-dependent E3 ubiquitin ligase activity. Mib and Mib2 are reciprocal E3 ubiquitin ligases and(More)
In this paper, an adaptive backstepping control scheme is proposed for stabilizing and controlling a class of uncertain chaotic systems. We firstly show that many chaotic systems as paradigms in the research of chaos can be transformed into a class of nonlinear systems in the feedback form. Unlike some existing control schemes for chaotic systems, no priori(More)
The extracellular matrix (ECM) is a dynamic composite of secreted proteins that play important roles in numerous biological processes such as tissue morphogenesis, differentiation and homeostasis. Furthermore, various diseases are caused by the dysfunction of ECM proteins. Therefore, identifying these important ECM proteins may assist in understanding(More)
The adaptive inverse control technology is utilized for induction machine (IM) control. Adaptive inverse control is actually an open-loop control scheme and so in the adaptive inverse control the instability problem caused by feedback control is avoided and the better dynamic performances can also be achieved. Linear LMS technique of adaptive inverse(More)
State-space models are proposed to represent multiple-input multiple-output (MIMO) frequency-selective wireless channels with the motivation of better model approximation and more robust channel equalization performance when the order of the channel model is lower that of the true channel. We develop a simple framework under which the equalizers for(More)
In this paper, we investigate the application of the subspace system identification (SSI) method (e.g. N4SID) to the MIMO frequency-selective fading channel estimation problem. The FIR constraint on the MIMO channel model is suggested to be relieved to draw benefit from possible parsimonious parametrization of the MIMO channel when subchannels become(More)