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Structural architecture of the CARMA1/Bcl10/MALT1 signalosome: nucleation-induced filamentous assembly.
The CARMA1/Bcl10/MALT1 (CBM) signalosome mediates antigen receptor-induced NF-κB signaling to regulate multiple lymphocyte functions. While CARMA1 and Bcl10 contain caspase recruitment domainsExpand
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The epichaperome is an integrated chaperome network that facilitates tumour survival
Transient, multi-protein complexes are important facilitators of cellular functions. This includes the chaperome, an abundant protein family comprising chaperones, co-chaperones, adaptors, andExpand
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Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2.
Although the Hsp90 chaperone family, comprised in humans of four paralogs, Hsp90α, Hsp90β, Grp94 and Trap-1, has important roles in malignancy, the contribution of each paralog to the cancerExpand
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The CBM signalosome: potential therapeutic target for aggressive lymphoma?
The CBM signalosome plays a pivotal role in mediating antigen-receptor induced NF-κB signaling to regulate lymphocyte functions. The CBM complex forms filamentous structure and recruits downstreamExpand
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Paralog-selective Hsp 90 inhibitors define tumor-specific regulation of Her 2
Although the Hsp90 chaperone family, comprised in humans of four paralogs, Hsp90α, Hsp90β, Grp94 and Trap-1, has important roles in malignancy, the contribution of each paralog to the cancerExpand
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Affinity Purification Probes of Potential Use To Investigate the Endogenous Hsp70 Interactome in Cancer
Heat shock protein 70 (Hsp70) is a family of proteins with key roles in regulating malignancy. Cancer cells rely on Hsp70 to inhibit apoptosis, regulate senescence and autophagy, and maintain theExpand
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Alterations in expressed prostate secretion-urine PSA N-glycosylation discriminate prostate cancer from benign prostate hyperplasia
The prostate specific antigen (PSA) test is widely used for early diagnosis of prostate cancer (PCa). However, its limited sensitivity has led to over-diagnosis and over-treatment of PCa.Expand
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A genomic and epigenomic atlas of prostate cancer in Asian populations
Prostate cancer is the second most common cancer in men worldwide 1 . Over the past decade, large-scale integrative genomics efforts have enhanced our understanding of this disease by characterizingExpand
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BASIC AND TRANSLATIONAL-PANCREAS
Setting off firecrackers: An economic way to release inner stress for patients with depression.
PURPOSE To advocate an economic way to release inner stress for patients with depression. CONCLUSIONS Setting off firecrackers has psychological value. It is not merely for fun, but is more anExpand