Chenggang Wu

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Shared-memory multiprocessors have dominated all platforms from high-end to desktop computers. On such platforms, it is well known that the interconnect between the processors and the main memory has become a major bottleneck. The bandwidth-aware job scheduling is an effective and relatively easy-to-implement way to relieve the bandwidth contention.(More)
Epithelial-mesenchymal transition (EMT), which can be caused by aberrant tyrosine kinase signalling, marks epithelial tumour progression and metastasis, yet the underlying molecular mechanism is not fully understood. Here, we report that Numb interacts with E-cadherin (E-cad) through its phosphotyrosine-binding domain (PTB) and thereby regulates the(More)
Src homology 2 (SH2) domains are the largest family of interaction modules encoded by the human genome to recognize tyrosine-phosphorylated sequences and thereby play pivotal roles in transducing and controlling cellular signals emanating from protein-tyrosine kinases. Different SH2 domains select for distinct phosphopeptides, and the function of a given(More)
Systematic identification of binding partners for modular domains such as Src homology 2 (SH2) is important for understanding the biological function of the corresponding SH2 proteins. We have developed a worldwide web-accessible computer program dubbed SMALI for scoring matrix-assisted ligand identification for SH2 domains and other signaling modules. The(More)
Building on work of Cai, Fürer, and Immerman [CFI92], we show two hardness results for the Graph Isomorphism problem. First, we show that there are pairs of nonisomorphic n-vertex graphs G and H such that any sum-of-squares (SOS) proof of nonisomorphism requires degree Ω(n). In other words, we show an Ω(n)round integrality gap for the Lasserre SDP(More)
Dynamic memory allocation is widely used in modern programs. General-purpose heap allocators often focus more on reducing their run-time overhead and memory space utilization, but less on exploiting the characteristics of their allocated heap objects. This paper presents a lightweight dynamic optimizer, named Dynamic Pool Allocation (DPA), which aims to(More)
Cross-ISA (Instruction Set Architecture) system-level virtual machine has a significant research and practical value. For example, several recently announced virtual smart phones for iOS which run smart phone applications on x86 based PCs are deployed on cross-ISA system level virtual machines. Also, for mobile device application development, by emulating(More)
A spore-forming, anaerobic, syntrophic fatty-acid-oxidizing bacterium, strain 19J-3(T), was isolated from a distilled-spirit-fermenting cellar in Hebei Province, China. The cells were slightly curved rods with a spore at the end of the cell. The optimal temperature for growth was around 37 degrees C and growth occurred in the range 25-45 degrees C. The pH(More)
The convergence of caspase and protein kinase signaling pathways has become increasingly evident, as illustrated by the protection of caspase substrates from cleavage upon undergoing phosphorylation at or near to their caspase recognition motifs. To investigate the global role of phosphorylation in the regulation of caspase signaling, we designed a peptide(More)
Two obligate anaerobic bacterial strains (5-3-Z(T) and Y4-1) were isolated from river sediment and rice field mud, respectively. They degraded straight-chain fatty acids with 4-8 carbon atoms in syntrophic association with methanogens, however, neither tested branch-chain fatty acids nor could benzoate be degraded. The strains formed spores when cocultured(More)