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Nonpeptide antigens, presentation mechanisms, and immunological memory of human Vγ2Vδ2 T cells: discriminating friend from foe through the recognition of prenyl pyrophosphate antigens
Summary:  Human Vγ2Vδ2 T cells play important roles in mediating immunity against microbial pathogens and have potent anti‐tumor activity. Vγ2Vδ2 T cells recognize the pyrophosphorylated isoprenoidExpand
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Cytokine Requirements for the Differentiation and Expansion of IL-17A– and IL-22–Producing Human Vγ2Vδ2 T Cells
Human γδ T cells expressing the Vγ2Vδ2 TCR play important roles in immune responses to microbial pathogens by monitoring prenyl pyrophosphate isoprenoid metabolites. Most adult Vγ2Vδ2 cells areExpand
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Flexible migration program regulates gamma delta T-cell involvement in humoral immunity.
gamma delta T cells are inadequately defined both in terms of their migration potential and contribution to antimicrobial immunity. Here, we have examined the migration profile of human blood gammaExpand
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Inequality of access to health care among the urban elderly in northwestern China.
OBJECTIVE The purpose of this study was to examine inequalities of access to health care among the urban elderly in northwestern China. METHODS 4441 seniors (over 60 years of age) were drawn from aExpand
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Preferential recognition of a microbial metabolite by human Vgamma2Vdelta2 T cells.
Human Vgamma2Vdelta2 T cells are stimulated by prenyl pyrophosphates, such as isopentenyl pyrophosphate (IPP), and play important roles in mediating immunity against microbial pathogens and haveExpand
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The Effect of New Cooperative Medical Scheme on Health Outcomes and Alleviating Catastrophic Health Expenditure in China: A Systematic Review
Background In 2002, the Chinese government launched a new rural health financing policy to provide health insurance (New Cooperative Medical Scheme, NCMS) for its rural population. NCMS, jointlyExpand
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Preferential recognition of a microbial metabolite by human Vγ2Vδ2 T cells
Human Vg2Vd2 T cells are stimulated by prenyl pyrophosphates, such as isopentenyl pyrophosphate (IPP), and play important roles in mediating immunity against microbial pathogens and have potentExpand
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Metabolic Engineering of Salmonella Vaccine Bacteria To Boost Human Vγ2Vδ2 T Cell Immunity
Human Vγ2Vδ2 T cells monitor isoprenoid metabolism by recognizing foreign (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), a metabolite in the 2-C-methyl-d-erythritol-4-phosphate pathway usedExpand
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Phenotypic and functional alterations of Vγ2Vδ2 T cell subsets in patients with active nasopharyngeal carcinoma
IntroductionHuman Vγ2Vδ2 T cells play important role in immunity to infection and cancer by monitoring self and foreign isoprenoid metabolites with their γδ T cell antigen receptors. Like CD4 and CD8Expand
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