Chengfeng Qin

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Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice.

Cui Li, Dan Xu, +7 authors Zhiheng Xu
Cell stem cell
2016

(Cell Stem Cell 19, 120–126; July 7, 2016) When this paper was originally published, the accession number for the RNA-seq dataset included in the study was unfortunately omitted. The dataset has now… (More)

Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody.

Lianpan Dai, Jian Song, +13 authors George Fu Gao
Cell host & microbe
2016

Zika virus (ZIKV), a mosquito-borne flavivirus, is a current global public health concern. The flavivirus envelope (E) glycoprotein is responsible for virus entry and represents a major target of… (More)

A Broadly Flavivirus Cross-Neutralizing Monoclonal Antibody that Recognizes a Novel Epitope within the Fusion Loop of E Protein

Yong-qiang Deng, Jian-xin Dai, +11 authors Chengfeng Qin
PloS one
2011

Flaviviruses are a group of human pathogenic, enveloped RNA viruses that includes dengue (DENV), yellow fever (YFV), West Nile (WNV), and Japanese encephalitis (JEV) viruses. Cross-reactive… (More)

Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice

Kong-Yan Wu, Guo-Long Zuo, +6 authors Zhen-Ge Luo
Cell Research
2016

The recent Zika virus (ZIKV) epidemic in Latin America coincided with a marked increase in microcephaly in newborns. However, the causal link between maternal ZIKV infection and malformation of the… (More)

A single nucleotide mutation in NS2A of Japanese encephalitis-live vaccine virus (SA14-14-2) ablates NS1' formation and contributes to attenuation.

Qing Ye, Xiao-Feng Li, +10 authors Chengfeng Qin
The Journal of general virology
2012

Japanese encephalitis (JE) remains the leading cause of viral encephalitis in the Asia-Pacific region, and the live vaccine SA14-14-2 is currently recommended by WHO and widely used in Asian… (More)

A single mutation in the prM protein of Zika virus contributes to fetal microcephaly

Ling Yuan, Xing-Yao Huang, +20 authors Chengfeng Qin
Science
2017

Zika virus (ZIKV) has evolved into a global health threat because of its unexpected causal link to microcephaly. Phylogenetic analysis reveals that contemporary epidemic strains have accumulated… (More)

25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model.

Chunfeng Li, Yong-qiang Deng, +29 authors Genhong Cheng
Immunity
2017

Zika virus (ZIKV) has become a public health threat due to its global transmission and link to severe congenital disorders. The host immune responses to ZIKV infection have not been fully elucidated,… (More)

Zika Virus Causes Testis Damage and Leads to Male Infertility in Mice

Wenqiang Ma, Shihua Li, +16 authors George Fu Gao
Cell
2016

Summary Zika virus (ZIKV) persists in the semen of male patients, a first for flavivirus infection. Here, we demonstrate that ZIKV can induce inflammation in the testis and epididymidis, but not in… (More)

Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses.

Yi Shi, Wei Zhang, +18 authors George Fu Gao
Science
2013

An avian-origin human-infecting influenza (H7N9) virus was recently identified in China. We have evaluated the viral hemagglutinin (HA) receptor-binding properties of two human H7N9 isolates,… (More)

Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes

Yang Liu, Jianying Liu, +10 authors Gong Cheng
Nature
2017

Zika virus (ZIKV) remained obscure until the recent explosive outbreaks in French Polynesia (2013–2014) and South America (2015–2016). Phylogenetic studies have shown that ZIKV has evolved into… (More)

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