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- Publications
- Influence
Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
- Zhenming Jin, Xiaoyu Du, +28 authors Haitao Yang
- Medicine
- Nature
- 9 April 2020
A new coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the aetiological agent responsible for the 2019–2020 viral pneumonia outbreak of coronavirus disease 2019… Expand
Structure of Mpro from COVID-19 virus and discovery of its inhibitors
- Zhenming Jin, Xiaoyu Du, +28 authors Haitao Yang
- Biology, Medicine
- medRxiv
- 27 February 2020
A new coronavirus (CoV) identified as COVID-19 virus is the etiological agent responsible for the 2019-2020 viral pneumonia outbreak that commenced in Wuhan1–4. Currently there is no targeted… Expand
Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice.
The link between Zika virus (ZIKV) infection and microcephaly has raised urgent global alarm. The historical African ZIKV MR766 was recently shown to infect cultured human neural precursor cells… Expand
Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells
- Yunlong Cao, Bin Su, +30 authors X. Xie
- Biology, Medicine
- Cell
- 18 May 2020
Summary
The COVID-19 pandemic urgently needs therapeutic and prophylactic interventions. Here we report the rapid identification of SARS-CoV-2 neutralizing antibodies by high-throughput… Expand
Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice.
(Cell Stem Cell 19, 120–126; July 7, 2016) When this paper was originally published, the accession number for the RNA-seq dataset included in the study was unfortunately omitted. The dataset has now… Expand
Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody.
Zika virus (ZIKV), a mosquito-borne flavivirus, is a current global public health concern. The flavivirus envelope (E) glycoprotein is responsible for virus entry and represents a major target of… Expand
Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice
- Kong-Yan Wu, Guo-Long Zuo, +6 authors Z. Luo
- Biology, Medicine
- Cell Research
- 13 May 2016
The recent Zika virus (ZIKV) epidemic in Latin America coincided with a marked increase in microcephaly in newborns. However, the causal link between maternal ZIKV infection and malformation of the… Expand
Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent Individuals
Summary
The World Health Organization has declared SARS-CoV-2 virus outbreak a world-wide pandemic. However, there is very limited understanding on the immune responses, especially adaptive… Expand
A single mutation in the prM protein of Zika virus contributes to fetal microcephaly
- Ling Yuan, Xing-Yao Huang, +20 authors Chengfeng Qin
- Biology, Medicine
- Science
- 17 November 2017
Mutation for microcephaly Zika virus infections in humans have been known since 1947. Microcephaly and neuropathologies associated with Zika have only been reported recently, most prevalently in the… Expand
A single nucleotide mutation in NS2A of Japanese encephalitis-live vaccine virus (SA14-14-2) ablates NS1' formation and contributes to attenuation.
- Q. Ye, X. Li, +10 authors Chengfeng Qin
- Biology, Medicine
- The Journal of general virology
- 1 September 2012
Japanese encephalitis (JE) remains the leading cause of viral encephalitis in the Asia-Pacific region, and the live vaccine SA14-14-2 is currently recommended by WHO and widely used in Asian… Expand