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Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy
TLDR
This work uncovers a function for PD-1 in exhausted T cell survival and suggests Gal-9 as a promising target for immunotherapy.
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An Overview of ADAM9: Structure, Activation, and Regulation in Human Diseases
TLDR
The current understanding of ADAM9 in biological function, pathophysiological diseases, and various cancers is summarized and recent advances in therapeutic strategies usingADAM9-related pathways are presented.
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Therapeutic effects of statins against lung adenocarcinoma via p53 mutant-mediated apoptosis
TLDR
Significantly higher levels of cellular apoptosis, inhibited cell growth, and regulated lipid raft content were observed in mutant p53 lung cancer cells treated with simvastatin, suggesting that statin use in selected lung cancer patients may have clinical benefits.
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The stabilization of PD-L1 by the endoplasmic reticulum stress protein GRP78 in triple-negative breast cancer.
TLDR
This study identified glucose regulatory protein 78 (GRP78), a major endoplasmic reticulum stress responding protein, as a novel binding partner of PD-L1, and revealed its interaction with GRP78, which modulates the response to chemotherapy and correlates with poor relapse-free survival in triple-negative breast cancer.
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Potential Prognostic Biomarkers of OSBPL Family Genes in Patients with Pancreatic Ductal Adenocarcinoma
TLDR
The functions of OSBPL family members were mainly associated with several potential signaling pathways in cancer cells, including ATP binding, integrin binding, receptor binding, and the renin-angiotensin system (RAS) signaling pathway.
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Cytomegalovirus Infection and Treatment in Allogeneic Hematopoietic Stem Cell Transplantation: A Retrospective Study from a Single Institution in an Endemic Area
TLDR
Prophylactic anti-CMV therapy might need to be considered for allo-HSCT recipients who have ≥grade III GVHD, which is a major complication after allogeneic hematopoietic stem cell transplantation.
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Bone cement‐induced pulmonary embolism in a myeloma patient
TLDR
Pulmonary thrombectomy may not be an effective treatment for bone cement-induced pulmonary embolism, and more attention should be focused on patients who experience dyspnoea after percutaneous vertebroplasty.
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Recurrent episodes of hemophagocytic lymphohistiocytosis preceding the diagnosis of subcutaneous panniculitis-like T-cell lymphoma
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Oxalate nephropathy related end-stage renal disease in a gallbladder cancer patient after Roux-en-Y surgery
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Immune Thrombocytopenia Induced by the Chimpanzee Adenovirus-Vectored Vaccine against SARS-CoV-2 Infection
TLDR
This case report showed that the chimpanzee adenovirus-vectored vaccine could also induce immune thrombocytopenia without the presence ofThrombosis, and should be cautious of this rare side effect as global vaccine administrations against coronavirus disease increase.
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