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A nonsynonymous functional variant in integrin-αM (encoded by ITGAM) is associated with systemic lupus erythematosus
We identified and replicated an association between ITGAM (CD11b) at 16p11.2 and risk of systemic lupus erythematosus (SLE) in 3,818 individuals of European descent. The strongest association was atExpand
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Monitoring receptor-ligand interactions between surfaces by thermal fluctuations.
We describe a new method for determining receptor-ligand association/dissociation events across the interface of two surfaces (two-dimensional binding) by monitoring abrupt decrease/resumption inExpand
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Drug repositioning for orphan diseases
TLDR
The need and opportunity to discover therapeutics for rare or orphan diseases are enormous. Expand
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Highly compressible 3D periodic graphene aerogel microlattices
Graphene is a two-dimensional material that offers a unique combination of low density, exceptional mechanical properties, large surface area and excellent electrical conductivity. Recent progressExpand
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A 3D Frontier-Based Exploration Tool for MAVs
TLDR
This paper presents a 3D frontier-based exploration tool named 3D-FBET. Expand
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Supercapacitors Based on Three-Dimensional Hierarchical Graphene Aerogels with Periodic Macropores.
Graphene is an atomically thin, two-dimensional (2D) carbon material that offers a unique combination of low density, exceptional mechanical properties, thermal stability, large surface area, andExpand
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3D-Printing of Meso-structurally Ordered Carbon Fiber/Polymer Composites with Unprecedented Orthotropic Physical Properties
Here we report the first example of a class of additively manufactured carbon fiber reinforced composite (AMCFRC) materials which have been achieved through the use of a latent thermal cured aromaticExpand
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An empirical study of Bayesian network parameter learning with monotonic influence constraints
TLDR
Learning the conditional probability table (CPT) parameters of Bayesian networks (BNs) is a key challenge in real-world decision support applications. Expand
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Single-mode chirally-coupled-core fibers with larger than 50 µm diameter cores.
In this paper, we report an advance in increasing core size of effective single-mode chirally-coupled-core (CCC) Ge-doped and Yb-doped double-clad fibers into 55 µm to 60 µm range, and experimentallyExpand
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Molecular Dynamics Simulations of Forced Unbending of Integrin αVβ3
TLDR
Integrins may undergo large conformational changes during activation, but the dynamic processes and pathways remain poorly understood. Expand
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