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The parasympathetic branch of the autonomic nervous system regulates the activity of multiple organ systems. Muscarinic receptors are G-protein-coupled receptors that mediate the response to acetylcholine released from parasympathetic nerves. Their role in the unconscious regulation of organ and central nervous system function makes them potential(More)
G-protein-coupled receptors (GPCRs) are eukaryotic integral membrane proteins that modulate biological function by initiating cellular signalling in response to chemically diverse agonists. Despite recent progress in the structural biology of GPCRs, the molecular basis for agonist binding and allosteric modulation of these proteins is poorly understood.(More)
Context. Although research in software engineering largely seeks to improve the practices and products of software development, many practices are based upon codification of expert knowledge, often with little or no underpinning from objective empirical evidence. Software design patterns seek to codify expert knowledge to share experience about successful(More)
Protease-activated receptor 1 (PAR1) is the prototypical member of a family of G-protein-coupled receptors that mediate cellular responses to thrombin and related proteases. Thrombin irreversibly activates PAR1 by cleaving the amino-terminal exodomain of the receptor, which exposes a tethered peptide ligand that binds the heptahelical bundle of the receptor(More)
b s t r a c t China's consumer-to-consumer (C2C) electronic market has been growing very rapidly. The largest Chinese online auction company. Eachnet. was purchased by eBay but faced tough competition from a new Chinese online auction company, Taobao. Now Taobao's market share is twice as large as eBay's. Why has eBay quickly lost its market share to the(More)
PURPOSE To elucidate the role of activated microglia in the photoreceptor apoptosis of rd mice by identifying sequential events and factors associated with microglial activation, migration, and cytotoxicity during retinal degeneration. METHODS Photoreceptor apoptosis in rd mice at postnatal days (P)8, 10, 12, 14, 16, and 18 was detected by terminal dUTP(More)
Programmers extensively use application programming interfaces (APIs) to leverage existing libraries and frameworks. However, correctly and efficiently choosing and using APIs from unfamiliar libraries and frameworks is still a non-trivial task. Programmers often need to ruminate on API documentations (that are often incomplete) or inspect code examples(More)
To identify new drug targets for the treatment of obesity, we employed a degenerate reverse transcriptasepolymerase chain reaction technique to isolate novel members of the G-protein coupled receptor superfamily from mouse hypothalamus. One of our clones was found to encode a protein with 90% amino acid identity to human GPR10, which was previously(More)
In product-oriented online social networks, members post product reviews as well as maintaining a list of friends. How to measure the influence a member receives from her friends? This study compares four models to measure the influence based on different theories which make various assumptions of member behavior in a social network. An empirical study was(More)