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Recognition of modified histone species by distinct structural domains within 'reader' proteins plays a critical role in the regulation of gene expression. Readers that simultaneously recognize histones with multiple marks allow transduction of complex chromatin modification patterns into specific biological outcomes. Here we report that chromatin regulator(More)
The Clinical Document Architecture, introduced by Health Level Seven, is a XML-based standard intending to specify the encoding, structure, and semantics of clinical documents for exchange. Since the clinical document is in XML form, its authenticity and integrity could be guaranteed by the use of the XML signature published by W3C. While a clinical(More)
SDF-1/CXCR4 signalling plays an important role in neuronal cell migration and brain development. However, the impact of CXCR4 deficiency in the postnatal mouse brain is still poorly understood. Here, we demonstrate the importance of CXCR4 on cerebellar development and motor behaviour by conditional inactivation of Cxcr4 in the central nervous system. We(More)
BACKGROUND Kocuria, established by Stackebrandt et al., previously was classified into Micrococcus. Only two species, K. rosea and K. kristinae are reported to be associated as pathogenic and found with catheter-related bacteremia and acute cholecystitis. CASE PRESENTATION We herein report the first case of brain abscess caused by Kocuria varians, a(More)
Extraventricular neurocytoma (EVN) in the spinal cord is extremely rare and only 15 cases have been reported in the English literature. Fourteen cases presented as an intramedullary lesion with spinal cord enlargement in cervico-thoracic segment and one case presented as an extramedullary lesion originating from cauda equina. Herein, we report an unusual(More)
INTRODUCTION Pedicle screws are commonly employed to restore spinal stability and correct deformities. The Renaissance robotic system was developed to improve the accuracy of pedicle screw placement. PURPOSE In this study, we developed an intraoperative classification system for evaluating the accuracy of pedicle screw placements through secondary(More)
This paper summarizes the work done by the authors for the Zero Resource Speech Challenge organized in the technical program of Interspeech 2015. The goal of the challenge is to discover linguistic units directly from unlabeled speech data. The Multi-layered Acoustic Tokenizer (MAT) proposed in this work automatically discovers multiple sets of acoustic(More)
The functional role of adult neurogenesis in the hippocampus remains the subject of intense speculation. One recent hypothesis is that adult-born neurons contribute to the endocrine and behavioural outputs of the stress response. Here we show a genetic model system to ablate neurogenesis by inducibly deleting Tbr2 gene function specifically in the(More)
# ABSTRACT In this work we aim to discover high quality speech features and linguistic units directly from unlabeled speech data in a zero resource scenario. The results are evaluated using the metrics and corpora proposed in the Zero Resource Speech Challenge organized at In-terspeech 2015. A Multi-layered Acoustic Tokenizer (MAT) was proposed for(More)