Cheng-Yi Wang

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INTRODUCTION Sepsis is the leading cause of acute kidney injury (AKI) in critical patients. The optimal timing of initiating renal replacement therapy (RRT) in septic AKI patients remains controversial. The objective of this study is to determine the impact of early or late initiation of RRT, as defined using the simplified RIFLE (risk, injury, failure,(More)
OBJECTIVES To investigate the determinants of outcome in patients with persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia. METHODS All patients >or=18 years old with MRSA bacteraemia for >or=7 days from 2000 to 2008 treated at National Taiwan University Hospital were investigated. The associations of mortality with clinical(More)
BACKGROUND Data about the efficacy and tolerability of linezolid for the treatment of gram-positive bacterial infections in patients with end-stage renal disease (ESRD) are lacking. METHODS This retrospective case-control study compared the tolerability and efficacy of linezolid therapy for patients with ESRD and patients with non-end-stage renal disease(More)
RATIONALE Triggering receptor expressed on myeloid cells (TREM)-1 is a molecule crucial for the triggering and amplification of inflammatory response and a new biomarker for sepsis. Tumor-associated macrophages and inflammation in the tumor microenvironment are also involved in cancer progression. OBJECTIVES To determine the role of TREM-1 in(More)
The incidence rate of AKI in hospitalized patients is increasing. However, relatively little attention has been paid to the association of AKI with long-term risk of adverse coronary events. Our study investigated hospitalized patients who recovered from de novo dialysis-requiring AKI between 1999 and 2008 using patient data collected from inpatient claims(More)
BACKGROUND This study took advantage of a large population-based database of the Taiwan National Health Insurance (NHI) to investigate the epidemiology of idiopathic pulmonary fibrosis (IPF) in Taiwan. METHODS This is a retrospective cohort study based on secondary analysis of prospectively collected data in the NHI system and governmental data on death(More)
Acute kidney injury (AKI) has a negative impact on long-term renal function and prognosis. However, the association between acute renal dysfunction and long-term effects on bone disorders has not yet been characterized. Using a population-based cohort study, we aimed to evaluate associations between AKI and long-term effects on bone fractures. We identified(More)
Tamoxifen, a selective estrogen receptor (ER) modulator, may affect cancer cell survival through mechanisms other than ER antagonism. In the present study, we tested the efficacy of tamoxifen in a panel of ER-negative breast cancer cell lines and examined the drug mechanism. In total, five ER-negative breast cancer cell lines (HCC-1937, MDA-MB-231,(More)
BACKGROUND The incidence of colorectal cancer is rising rapidly in some Asian countries. OBJECTIVE To determine the prevalence and the distribution of colorectal neoplasm in Asian populations. DESIGN A multicenter colonoscopy survey. PATIENTS Between July 2004 and April 2005, consecutive symptomatic patients undergoing colonoscopic examinations in 10(More)