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Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket*
Background: Up-regulated pyruvate dehydrogenase kinase isoforms (PDKs) are associated with impaired glucose homeostasis in diabetes. Results: Novel PDK inhibitors were developed using structure-basedExpand
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Biodegradable poly(lactic acid)/chitosan-modified montmorillonite nanocomposites: Preparation and characterization
Abstract In this study, the biodegradable poly(lactic acid) (PLA)/montmorillonite (MMT) nanocomposites were successfully prepared by the solution mixing process of PLA polymer withExpand
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Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain α-Ketoacid Dehydrogenase Kinase*
Background: Branched-chain amino acids (BCAA) are elevated in maple syrup urine disease, obesity, and type 2 diabetes. Results: We show that benzothiophene carboxylate derivatives are allostericExpand
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Targeting hepatic pyruvate dehydrogenase kinases restores insulin signaling and mitigates ChREBP-mediated lipogenesis in diet-induced obese mice
Objective Mitochondrial pyruvate dehydrogenase kinases 1–4 (PDKs1–4) negatively regulate activity of the pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDKs play a pivotal roleExpand
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Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors.
Pyruvate dehydrogenase kinases 1-4 (PDK1-4) negatively control activity of the pyruvate dehydrogenase complex (PDC) and are up-regulated in obesity, diabetes, heart failure, and cancer. We reportedExpand
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The preparation of piezoelectric ZnO films by RF magnetron sputtering for layered surface acoustic wave device applications
Crystalline structures, intrinsic stress, and surface roughness of piezoelectric ZnO films deposited on sapphire substrates by rf magnetron sputtering and sequential post-annealing treatments wereExpand
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Organosilicon/silicon oxide gas barrier structure encapsulated flexible plastic substrate by using plasma-enhanced chemical vapor deposition
Abstract An organosilicon/silicon oxide (SiO x ) multilayered barrier structure was consecutively deposited onto the polyethylene terephthalate (PET) substrate by plasma-enhanced chemical vaporExpand
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The Preparation of (8-Hydroxyquinolinato)bis(2-phenylpyridyl)iridium Complexes and Their Photophysical Properties
Four derivatives of the titled compounds, (8-hydroxyquinoline)bis(2-phenylpyridyl)iridium (IrQ(PPy) 2 ), were prepared. Two of them were confirmed by single crystal X-ray diffraction analyses, inExpand
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Determination of photocatalytic activity in amorphous and crystalline titanium oxide films prepared using plasma-enhanced chemical vapor deposition
Abstract Hydro-oxygenated amorphous titanium oxide (a-TiOx:OH) films were prepared by plasma-enhanced chemical vapor deposition (PECVD) using precursors of titanium tetraisopropoxide (TTIP) andExpand
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Effect of nickel oxide seed layers on annealed-amorphous titanium oxide thin films prepared using plasma-enhanced chemical vapor deposition
Abstract The effect of a nickel oxide (NiO x ) seed layer on the crystallization and photocatalytic activity of the sequentially plasma-enhanced chemical vapor deposited amorphous titanium oxide (TiOExpand
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