Cheng Weng Fong

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Recent evidence shows that secretory phospholipase A2 (sPLA2) may play a role in membrane fusion and fission, and may thus affect neurotransmission. The present study therefore aimed to elucidate the effects of sPLA2 on vesicle exocytosis. External application of group IIA sPLA2 (purified crotoxin subunit B or purified human synovial sPLA2) caused an(More)
Direct measures of G-protein activation based on guanine nucleotide exchange and hydrolysis are frequently impossible to monitor for receptors which interact predominantly with G(s)alpha. An isolated FLAG (Asp-Tyr-Lys-Asp-Asp-Asp-Asp-Lys)-epitope-tagged human IP prostanoid receptor and fusion proteins generated between this form of the receptor and the(More)
A FLAG-tagged form of the human IP prostanoid receptor was expressed stably in HEK 293 cells. This bound [3H]iloprost with high affinity and stimulated cAMP production when exposed to agonist. Iloprost produced weak stimulation of GTPase activity and [35S]guanosine-5'-O-(3-thio)triphosphate binding in membranes of these cells. Pretreatment of cells with(More)
This work applies a hybrid approach in solving the university curriculum-based course timetabling problem as presented as part of the 2 International Timetabling Competition 2007 (ITC2007). The core of the hybrid approach is based on an artificial bee colony algorithm. Past methods have applied artificial bee colony algorithms to university timetabling(More)
Course Timetable Problem (CTTP) is considered as a multiassignments problem. This problem occurs during the assignment of a set of events (courses, subjects and teachers) to specific number of appointments (timeslots, days and rooms) under a set of hard and soft constraints. In this paper, the proposed algorithm is represented for solving the CTTP based on(More)
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