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  • Wei-Chung Cheng, Min-Lung Tsai, +8 authors Ian C. Hsu
  • Computer Science, Medicine
  • BMC Bioinformatics
  • 2010 (First Publication: 10 August 2010)
  • BackgroundOver the past decade, gene expression microarray studies have greatly expanded our knowledge of genetic mechanisms of human diseases. Meta-analysis of substantial amounts of accumulatedContinue Reading
  • Huawei Chen, Hiroshi Yamase, +4 authors Hung-Wen Liu
  • Chemistry, Medicine
  • Biochemistry
  • 2002 (First Publication: 1 July 2002)
  • Methylation catalyzed by an S-adenosylmethionine- (AdoMet-) dependent methyltransferase is an effective means to alter the hydrophilicity and/or nucleophilicity of a molecule. While a large number ofContinue Reading
  • Virginia B. Mattis, Allison D. Ebert, Marina Y. Fosso, Cheng-Wei Chang, Christian L. Lorson
  • Biology, Medicine
  • Human molecular genetics
  • 2009 (First Publication: 15 October 2009)
  • Spinal muscular atrophy (SMA) is the leading genetic cause of infant mortality and is caused by the loss of a functional SMN1 gene. In humans, there exists a nearly-identical copy gene known as SMN2Continue Reading
  • Tzong-Yi Lee, Cheng-Wei Chang, Cheng-Tsung Lu, Tzu-Hsiu Cheng, Tzu-Hao Chang
  • Computer Science, Medicine, Biology
  • Comput. Biol. Chem.
  • 2014 (First Publication: 1 June 2014)
  • Protein methylation is a kind of post-translational modification (PTM), and typically takes place on lysine and arginine amino acid residues. Protein methylation is involved in many importantContinue Reading