Cheng Tiong

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BACKGROUND Itraconazole is believed to carry a low risk of hepatic toxicity owing to its low affinity for the human P-450 enzyme. Therefore, hepatic failure caused by itraconazole is exceedingly rare. OBJECTIVES We report the case of a 46-year-old woman who developed hepatic failure related to itraconazole that was administered for the treatment of(More)
Early-life sleep deprivation (ESD) is a serious condition with severe metabolic sequelae. The pineal hormone melatonin plays an important role in homeostatic regulation of metabolic function. Considering norepinephrine-mediated Ca2+ influx and subsequent protein kinase A (PKA) activation is responsible for downstream cAMP-response element-binding protein(More)
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