Cheng-Jie Yang

We don’t have enough information about this author to calculate their statistics. If you think this is an error let us know.
Learn More
In our continuing search for camptothecin (CPT)-derived antitumor drugs, novel 7-substituted CPT derivatives incorporating piperazinyl-sulfonylamidine moieties were designed, synthesized and evaluated for cytotoxicity against five tumor cell lines (A-549, MDA-MB-231, MCF-7, KB, and KB-VIN). All of the derivatives showed promising in vitro cytotoxic activity(More)
Fluorination is a well-known strategy for improving the bioavailability of bioactive molecules in the lead optimization phase of drug discovery projects. In an attempt to improve the antitumor activity of camptothecins (CPTs), novel 10-fluoro-CPT derivatives were designed, synthesized and evaluated for cytotoxicity against five human cancer cell lines(More)
To overcome the deterioration of azimuth resolution caused by errors of monopulse response curve (MRC) in practical processing, this paper proposes an auto-focusing algorithm for monopulse imaging technique. By applying iterative steps, this algorithm automatically extracts the echo signals of isolated strong scatterers from the received data, and employs(More)
  • 1