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In this work, we conducted a case study of a popular Chinese microblogging site, Sina-Weibo, to investigate how Chinese netizens used microblogging in response to a major disaster: the 2010 Yushu Earthquake. We combined multiple analysis methods in this case study, including content analysis of microblog messages, trend analysis of different topics, and an(More)
Caveolin-1 (Cav-1), a principal structural component of caveolar membrane domains, contributes to cancer development but its precise functional roles and regulation remain unclear. In this study, we determined the oncogenic function of Cav-1 in preclinical models of pancreatic cancer and in human tissue specimens. Cav-1 expression levels correlated with(More)
Signatures and handwriting have long played a role in day-today business transactions and in forensics, e.g., to authenticate documents , as evidence to establish crime or innocence, etc. The individuality of handwriting and signatures is the basis for their relevance to authenti-cation and forensics. This very individuality makes them also potentially(More)
A system for spotting words in scanned document images in three scripts, Devanagari, Ara-bic and Latin is described. Three main components of the system are a word segmenter, a shape based matcher for words and a search interface. The user gives a query which can be either a word image or text. The candidate words that are searched in the documents are(More)
MicroRNAs are a group of small non-coding RNAs that modulate gene expression. The de-regulation of microRNA expression has been found in several types of cancer. To study the role of microRNAs in gastric cancer (GC), we analyzed the expression profile of 847 microRNAs in GC from Chinese patients. Total RNA was used for hybridization on the miRCURY LNA Array(More)
The aim of this study was to assess the significance of expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and associated proteins in pancreatic ductal adenocarcinoma (PDA) and their impact on prognosis. Expression of HIF-1alpha, vascular endothelial growth factor (VEGF), glucose transporter-1 (Glut-1), survivin, CD34 and Ki-67 and apoptotic cells(More)
Tyrosyl-DNA phosphodiesterase 1 (Tdp1) cleaves the phosphodiester bond between a covalently stalled topoisomerase I (Topo I) and the 3' end of DNA. Stalling of Topo I at DNA strand breaks is induced by endogenous DNA damage and the Topo I-specific anticancer drug camptothecin (CPT). The H493R mutation of Tdp1 causes the neurodegenerative disorder(More)
Lactotransferrin (LTF) has been shown to regulate tumorogenesis. However, little is known about the role of LTF in regulating the development of human nasopharyngeal carcinoma (NPC). The aim of our study was to investigate whether LTF could regulate the development of NPC by characterizing the pattern of LTF expression in human NPC tissues using cDNA and(More)
Hepatitis B virus (HBV) is a major cause of liver disease and hepatocellular carcinoma. Chronic HBV infection is currently managed with either nucleoside/nucleotide-based or interferon-based therapies, but fails to clear infection in a substantial proportion of cases, and antiviral strategies targeting the early stages of infection are therefore required(More)