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BACKGROUND Recent advance in genetic studies added the confirmed susceptible loci for type 2 diabetes to eighteen. In this study, we attempt to analyze the independent and joint effect of variants from these loci on type 2 diabetes and clinical phenotypes related to glucose metabolism. METHODS/PRINCIPAL FINDINGS Twenty-one single nucleotide polymorphisms(More)
Substantial progress has been made in identification of type 2 diabetes (T2D) risk loci in the past few years, but our understanding of the genetic basis of T2D in ethnically diverse populations remains limited. We performed a genome-wide association study and a replication study in Chinese Hans comprising 8,569 T2D case subjects and 8,923 control subjects(More)
In this paper, a class of fractional-order neural networks is investigated. First, α-exponential stability is introduced as a new type of stability and some effective criteria are derived for such kind of stability of the addressed networks by handling a new fractional-order differential inequality. Based on the results, the existence and α-exponential(More)
With rapidly increasing prevalence, diabetes has become one of the major causes of mortality worldwide. According to the latest studies, genetic information makes substantial contributions towards the prediction of diabetes risk and individualized antidiabetic treatment. To date, approximately 70 susceptibility genes have been identified as being associated(More)
OBJECTIVE Diabetic nephropathy and retinopathy are two important microvascular diabetes complications with a high concordance rate in diabetic patients. A recent genome-wide association study in type 1 diabetic patients of European descent identified four loci to be associated with diabetic nephropathy. The aim of this study was to test the effects of(More)
Roots are involved in acquisition of water and nutrients, as well as in providing structural support to plant. The root system provides a dynamic model for developmental analysis. Here, we investigated quantitative trait loci (QTL), dynamic conditional QTL and epistatic interactions for seedling root traits using an upland cotton F2 population and a(More)
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of(More)
This paper discuss the global exponential stability and synchronization of the delayed reaction-diffusion neural networks with Dirichlet boundary conditions under the impulsive control in terms of p-norm and point out the fact that there is no constant equilibrium point other than the origin for the reaction-diffusion neural networks with Dirichlet boundary(More)
In this paper, the exponential lag synchronization for a class of neural networks with discrete delays and distributed delays is studied via periodically intermittent control for the first time. Some novel and useful criteria are derived by using mathematical induction method and the analysis technique which are different from the methods employed in(More)