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BACKGROUND Recent advance in genetic studies added the confirmed susceptible loci for type 2 diabetes to eighteen. In this study, we attempt to analyze the independent and joint effect of variants from these loci on type 2 diabetes and clinical phenotypes related to glucose metabolism. METHODS/PRINCIPAL FINDINGS Twenty-one single nucleotide polymorphisms(More)
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of(More)
This paper discuss the global exponential stability and synchronization of the delayed reaction-diffusion neural networks with Dirichlet boundary conditions under the impulsive control in terms of p-norm and point out the fact that there is no constant equilibrium point other than the origin for the reaction-diffusion neural networks with Dirichlet boundary(More)
To identify the genetic bases for nine metabolic traits, we conducted a meta-analysis combining Korean genome-wide association results from the KARE project (n = 8,842) and the HEXA shared control study (n = 3,703). We verified the associations of the loci selected from the discovery meta-analysis in the replication stage (30,395 individuals from the(More)
In this paper, the exponential lag synchronization for a class of neural networks with discrete delays and distributed delays is studied via periodically intermittent control for the first time. Some novel and useful criteria are derived by using mathematical induction method and the analysis technique which are different from the methods employed in(More)
OBJECTIVES To evaluate haemoglobin A1c (HbA(1c)) in diagnosing diabetes and identify the optimal HbA(1c) threshold to be used in Chinese adults. DESIGN Multistage stratified cross sectional epidemiological survey. SETTING Shanghai, China, 2007-8. PARTICIPANTS 4886 Chinese adults over 20 years of age with no history of diabetes. MAIN OUTCOME MEASURES(More)
Substantial progress has been made in identification of type 2 diabetes (T2D) risk loci in the past few years, but our understanding of the genetic basis of T2D in ethnically diverse populations remains limited. We performed a genome-wide association study and a replication study in Chinese Hans comprising 8,569 T2D case subjects and 8,923 control subjects(More)
AIM The aim was to investigate the association between human insulin and cancer incidence and mortality in Chinese patients with type 2 diabetes. METHODS We recruited 8,774 insulin-naïve diabetes patients from the Shanghai Diabetes Registry (SDR). The follow-up rate was 85.4%. All subjects were divided into the insulin use cohort (n = 3,639) and the(More)
In this paper, a class of fractional-order neural networks is investigated. First, α-exponential stability is introduced as a new type of stability and some effective criteria are derived for such kind of stability of the addressed networks by handling a new fractional-order differential inequality. Based on the results, the existence and α-exponential(More)
BACKGROUND Single nucleotide polymorphisms (SNPs) from GCK, GCKR, G6PC2 and MTNR1B were found to modulate the fasting glucose levels. The current study aimed to replicate this association in the Chinese population and further analyze their effects on biphasic insulin secretion. METHODS/PRINCIPAL FINDINGS SNPs from GCK, GCKR, G6PC2 and MTNR1B were(More)