Cheng-Hsin Chuang

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While arsenic trioxide (As2O3) is an infamous carcinogen, it is also an effective chemotherapeutic agent for acute promyelocytic leukemia and some solid tumors. In human epidermoid carcinoma A431 cells, we found that As2O3 induced cell death in time- and dose-dependent manners. Similarly, dependent regulation of the p21WAF1/CIP1 (p21) promoter, mRNA(More)
A multiplexed immunosensor has been developed for the detection of specific biomarkers Galectin-1 (Gal-1) and Lactate Dehydrogenase B (LDH-B) present in different grades of bladder cancer cell lysates. In order to immobilize nanoprobes with different antibodies on a single chip we employed three-step programmable dielectrophoretic manipulations for(More)
This paper develops a dielectrophoretic (DEP) chip with multi-layer electrodes and a micro-cavity array for programmable manipulations of cells and impedance measurement. The DEP chip consists of an ITO top electrode, flow chamber, middle electrode on an SU-8 surface, micro-cavity arrays of SU-8 and distributed electrodes at the bottom of the micro-cavity.(More)
Establishing the neighbor list to efficiently calculate the inter-atomic forces consumes the majority of computation time in molecular dynamics (MD) simulation. Several algorithms have been proposed to improve the computation efficiency for short-range interaction in recent years, although an optimized numerical algorithm has not been provided. Based on a(More)
Grasping an object of unknown weight is the most important demand for a robot. However, the control of the grasping force needs the detection of slippage to prevent the object falling from the robot's fingers. A novel flexible tactile sensor consists of piezoelectric and piezoresistive transducers for detecting incidents of slippage and contact force,(More)
—This study provides an efficient and feasible solution to enhance the sensitivity of traditional piezoelectric tactile sensor based on introducing structural electrode upon the sensing material. A sandwich structure for flexible tactile sensor consists of top and bottom soft substrates made of Polystyrene, and in between of two soft substrates a(More)
Cell characterization analysis usually involves a sequence of steps such as culture, separation, trapping, examination and recollection. In general, it is difficult to recover the identified cells and achieve a multi-run examination on a single chip for clinical samples. In the present study, a dielectrophoresis (DEP) micro-device was developed for(More)
The melting duration and molten depth are key information for laser-assisted direct imprinting, which raises issues about the melting & solidification induced by excimer-pulse-laser irradiating through unilaterally transparent binary materials. Considering the size-effect on thermal conductivity and phase-change of irradiated material, the(More)
* Abstract – This paper presents a microfluidic chip with arc-shape electrodes array (ASEA) for separation of different-size particles/Cells based on negative dielectrophoresis (nDEP). The purpose of ASEA is to generate the dielectrophoretic force perpendicular to the microchannel direction within the gap between each pairs of arc-shape electrodes. The DEP(More)