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Microtubule-associated protein tau is abnormally hyperphosphorylated in Alzheimer's disease (AD) and other tauopathies and is believed to lead to neurodegeneration in this family of diseases. Here we show that infusion of forskolin, a specific cAMP-dependent protein kinase A (PKA) activator, into the lateral ventricle of brain in adult rats induced(More)
In Alzheimer's disease (AD) brain, microtubule-associated protein tau is abnormally modified by hyperphosphorylation and glycosylation, and is aggregated as neurofibrillary tangles of paired helical filaments. To investigate the role of tau glycosylation in neurofibrillary pathology, we isolated various pools of tau protein from AD brain which represent(More)
There is an urgent need to make cisplatin (cDDP) more effective and less toxic in the treatment of ovarian cancer for its systemic side effects and high resistance rate. In this study, we investigated the effect of quercetin (Qu) pretreatment on the potentiation of cDDP in ovarian cancer. We found that Qu pretreatment significantly enhanced cDDP(More)
Recently, long noncoding RNAs (lncRNAs) have been identified as critical regulators in numerous types of cancers, including non-small cell lung cancer (NSCLC). X inactivate-specific transcript (XIST) has been found to be up-regulated and acts as an oncogene in gastric cancer and hepatocellular carcinoma, but little is known about its expression pattern,(More)
Aggregation of abnormal hyperphosphorylated tau to neurofibrillary tangles in affected neurons is one of the hallmarks for Alzheimer disease (AD). Studies during the last decade have strongly suggested that hyperphosphorylation of tau is site-specifically responsible for the loss of biological activity, the gain of toxic activity, and the aggregation into(More)
Metro systems are one of the most important transportation systems in people’s lives. Due to the huge amount of energy it consumes every day, highly-efficient operation of a metro system will lead to significant energy savings. In this paper, a new integrated Energy-efficient Operation Methodology (EOM) for metro systems is proposed and validated. Compared(More)
cific PCR testing of 1 nasopharyngeal swab and 2 BAL fluid samples confirmed our clinical suspicion of ARDS secondary to EV-D68 in an adult. The patient’s history of contact with sick family members and clinical signs (nonproductive cough, nausea, and vomiting) were suggestive of a viral infection. Lessons learned from the emergence of swine-origin(More)
Large-scale sensor deployment and coverage of wireless sensor networks (WSNs) is one of the most important topics for real applications, especially on real terrain surface, such as forest monitoring. In our works, we exploit the Digital Elevation Model (DEM) in Geographic Information System to describe the real fields for sensors. An algorithm for sensor(More)
Statistical fault localization techniques analyze the dynamic program information provided by executing a large number of test cases to predict fault positions in faulty programs. Related studies show that the extent of imbalance between the number of passed test cases and that of failed test cases may reduce the effectiveness of such techniques, while(More)