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  • Kaipeng Huang, Juan Huang, +5 authors Heqing Huang
  • Chemistry, Medicine
  • Free radical biology & medicine
  • 2013 (First Publication: 1 December 2013)
  • Advanced glycation end products (AGEs) boost the generation of reactive oxygen species (ROS) in glomerular mesangial cells (GMCs), and thereby play important roles in diabetic nephropathy (DN).Continue Reading
  • Nan Chen, Li Ping Chen, +5 authors Huan Wang
  • Biology, Medicine
  • Gene
  • 2012 (First Publication: 1 April 2012)
  • Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in oxygen tension in the cellular environment. In this study, we identified full-length cDNAs of HIF-1α, HIF-2α andContinue Reading
  • Hui Chen, Jianping Sun, +4 authors Wei Shi
  • Biology, Medicine
  • American journal of physiology. Lung cellular and…
  • 2005 (First Publication: 1 April 2005)
  • Transforming growth factor-beta (TGF-beta) signaling plays an important regulatory role during lung development and remodeling. Smad3 is a major downstream signal transducer in the TGF-beta pathwayContinue Reading
  • Wei Chen, Xin-Ke Xu, +8 authors Fang-cheng Li
  • Medicine
  • Oncotarget
  • 2017 (First Publication: 8 February 2017)
  • Glioblastoma multiforme (GBM) is the most malignant brain tumor with limited therapeutic options. Temozolomide (TMZ) is a novel cytotoxic agent used as first-line chemotherapy for GBM, however, someContinue Reading
  • Francois Y.L. Li, Karen Siu Ling Lam, +4 authors Aimin Xu
  • Medicine
  • Circulation
  • 2012 (First Publication: 4 September 2012)
  • BACKGROUND Endothelial damage and dysfunction are crucial mediators that link diabetes mellitus with atherosclerotic cardiovascular disease. AMP-activated kinase (AMPK) has been implicated inContinue Reading