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Convolutional neural network (CNN) has been widely employed for image recognition because it can achieve high accuracy by emulating behavior of optic nerves in living creatures. Recently, rapid growth of modern applications based on deep learning algorithms has further improved research and implementations. Especially, various accelerators for deep CNN have(More)
Software development has traditionally been regarded as an activity that can only be effectively conducted and managed within a firm setting. However, contrary to such assertions, the open source software development (OSSD) approach, in which software developers in Internet-based communities coordinate to voluntarily contribute programming code, has(More)
Project ExScal (for Extreme Scale) fielded a 1000+ node wireless sensor network and a 200+ node peer-to-peer ad hoc network of 802.11 devices in a 1.3km by 300m remote area in Florida, USA during December 2004. In comparison with previous deployments, the ExScal application is relatively complex and its networks are the largest ones of either type fielded(More)
Postsynaptic neuroligins are thought to perform essential functions in synapse validation and synaptic transmission by binding to, and dimerizing, presynaptic alpha- and beta-neurexins. To test this hypothesis, we examined the functional effects of neuroligin-1 mutations that impair only alpha-neurexin binding, block both alpha- and beta-neurexin binding,(More)
In recent years, genome-wide association studies (GWASs) have identified many novel susceptible genes/loci for Alzheimer’s disease (AD). However, most of these studies were conducted in European and populations of European origin, and limited studies have been performed in Han Chinese. In this study, we genotyped 14 single-nucleotide polymorphisms (SNPs) in(More)
Efficient optical clearance is fundamental for whole brain imaging. In particular, clearance of the brain without membrane damage is required for the imaging of lipophilic tracer-labeled neural tracts. Relying on an ascending gradient of fructose solutions, SeeDB can achieve sufficient transparency of the mouse brain while ensuring that the plasma membrane(More)
Here we describe a novel mechanism for plasma membrane insertion of the delta opioid receptor (DOR). In small dorsal root ganglion neurons, only low levels of DORs are present on the cell surface, in contrast to high levels of intracellular DORs mainly associated with vesicles containing calcitonin gene-related peptide (CGRP). Activation of surface DORs(More)
The expression pattern and function of miRNAs in the rat model of temporal lobe epilepsy have not been well defined. Profiling miRNA expression in the rat model of temporal lobe epilepsy and investigating the function of specific miRNAs in epilepsy offers the prospect of a deeper understanding of the mechanisms of epilepsy. The lithium-pilocarpine-induced(More)
Memory partitioning is widely adopted to efficiently increase the memory bandwidth by using multiple memory banks and reducing data access conflict. Previous methods for memory partitioning mainly focused on one-dimensional arrays. As a consequence, designers must flatten a multidimensional array to fit those methodologies. In this work we propose an(More)