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The Architecture of the Adhesive Apparatus of Cultured Osteoclasts: From Podosome Formation to Sealing Zone Assembly
Background Osteoclasts are bone-degrading cells, which play a central role in physiological bone remodeling. Unbalanced osteoclast activity is largely responsible for pathological conditions such asExpand
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Developmental roles for Srf, cortical cytoskeleton and cell shape in epidermal spindle orientation
During development, a polarized epidermal sheet undergoes stratification and differentiation to produce the skin barrier. Through mechanisms that are poorly understood, the process involves actinExpand
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Involvement of the Src-cortactin pathway in podosome formation and turnover during polarization of cultured osteoclasts
Osteoclasts are large, multinucleated cells that adhere to bone via podosomes, and degrade it. During osteoclast polarization, podosomes undergo reorganization from a scattered distribution, throughExpand
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Involvement of actin polymerization in podosome dynamics
Podosomes, which are formed by different monocyte derivatives, are small adhesion structures whose coordinated dynamics and cytoskeletal reorganization drive their motile and invasive features. UsingExpand
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The molecular dynamics of osteoclast adhesions.
Podosomes are specialized adhesive structures that play a central role in bone resorption. In this article we address the molecular diversity and dynamics of podosomes at different states ofExpand
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Tyrosine phosphatase epsilon is a positive regulator of osteoclast function in vitro and in vivo.
Protein tyrosine phosphorylation is a major regulator of bone metabolism. Tyrosine phosphatases participate in regulating phosphorylation, but roles of specific phosphatases in bone metabolism areExpand
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Wdr1-mediated cell shape dynamics and cortical tension are essential for epidermal planar cell polarity
During mouse development, core planar cell polarity (PCP) proteins become polarized in the epidermal plane to guide angling/morphogenesis of hair follicles. How PCP is established is poorlyExpand
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The contractome – a systems view of actomyosin contractility in non-muscle cells
ABSTRACT Actomyosin contractility is a highly regulated process that affects many fundamental biological processes in each and every cell in our body. In this Cell Science at a Glance article and theExpand
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T-plastin is essential for basement membrane assembly and epidermal morphogenesis
The actin-bundling protein T-plastin and the cortical cytoskeleton ensure that the epidermal basement membrane develops properly. T-plastin required for basement membrane assembly The basementExpand
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Mechanisms of cell adhesion and migration
Adhesion to the extracellular matrix (ECM) or to neighboring cells regulates multiple cellular processes such as cell migration, morphogenesis, proliferation, gene expression and survival. ActivationExpand
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