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- Publications
- Influence
The Architecture of the Adhesive Apparatus of Cultured Osteoclasts: From Podosome Formation to Sealing Zone Assembly
- Chen Luxenburg, Dafna Geblinger, +4 authors L. Addadi
- Chemistry, Medicine
- PloS one
- 31 January 2007
Background Osteoclasts are bone-degrading cells, which play a central role in physiological bone remodeling. Unbalanced osteoclast activity is largely responsible for pathological conditions such as… Expand
Developmental roles for Srf, cortical cytoskeleton and cell shape in epidermal spindle orientation
- Chen Luxenburg, H. Pasolli, S. Williams, E. Fuchs
- Biology, Medicine
- Nature Cell Biology
- 1 March 2011
During development, a polarized epidermal sheet undergoes stratification and differentiation to produce the skin barrier. Through mechanisms that are poorly understood, the process involves actin… Expand
Involvement of the Src-cortactin pathway in podosome formation and turnover during polarization of cultured osteoclasts
- Chen Luxenburg, J. Parsons, L. Addadi, B. Geiger
- Biology, Medicine
- Journal of Cell Science
- 1 December 2006
Osteoclasts are large, multinucleated cells that adhere to bone via podosomes, and degrade it. During osteoclast polarization, podosomes undergo reorganization from a scattered distribution, through… Expand
Involvement of actin polymerization in podosome dynamics
- Chen Luxenburg, S. Winograd-Katz, L. Addadi, B. Geiger
- Biology, Medicine
- Journal of Cell Science
- 1 April 2012
Podosomes, which are formed by different monocyte derivatives, are small adhesion structures whose coordinated dynamics and cytoskeletal reorganization drive their motile and invasive features. Using… Expand
The molecular dynamics of osteoclast adhesions.
- Chen Luxenburg, L. Addadi, B. Geiger
- Biology, Medicine
- European journal of cell biology
- 7 April 2006
Podosomes are specialized adhesive structures that play a central role in bone resorption. In this article we address the molecular diversity and dynamics of podosomes at different states of… Expand
Tyrosine phosphatase epsilon is a positive regulator of osteoclast function in vitro and in vivo.
- R. Chiusaroli, H. Knobler, +7 authors A. Elson
- Biology, Medicine
- Molecular biology of the cell
- 3 October 2003
Protein tyrosine phosphorylation is a major regulator of bone metabolism. Tyrosine phosphatases participate in regulating phosphorylation, but roles of specific phosphatases in bone metabolism are… Expand
Wdr1-mediated cell shape dynamics and cortical tension are essential for epidermal planar cell polarity
- Chen Luxenburg, E. Heller, +4 authors E. Fuchs
- Biology, Medicine
- Nature Cell Biology
- 1 May 2015
During mouse development, core planar cell polarity (PCP) proteins become polarized in the epidermal plane to guide angling/morphogenesis of hair follicles. How PCP is established is poorly… Expand
The contractome – a systems view of actomyosin contractility in non-muscle cells
- R. Zaidel-Bar, Guo Zhen-huan, Chen Luxenburg
- Biology, Medicine
- Journal of Cell Science
- 15 June 2015
ABSTRACT Actomyosin contractility is a highly regulated process that affects many fundamental biological processes in each and every cell in our body. In this Cell Science at a Glance article and the… Expand
T-plastin is essential for basement membrane assembly and epidermal morphogenesis
- E. Dor-On, S. Raviv, Y. Cohen, O. Adir, Krishnanand Padmanabhan, Chen Luxenburg
- Biology, Medicine
- Science Signaling
- 30 May 2017
The actin-bundling protein T-plastin and the cortical cytoskeleton ensure that the epidermal basement membrane develops properly. T-plastin required for basement membrane assembly The basement… Expand
Mechanisms of cell adhesion and migration
- B. Geiger, I. Lavelin, +13 authors Anat Florentin
- Biology
- 2006
Adhesion to the extracellular matrix (ECM) or to neighboring cells regulates multiple cellular processes such as cell migration, morphogenesis, proliferation, gene expression and survival. Activation… Expand
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