Discriminative stimulus functions of methanandamide and ∆9-THC in rats: tests with aminoalkylindoles (WIN55,212-2 and AM678) and ethanol
Data are congruent with the general observation that there is substantial overlap in the discriminative stimulus effects of CB1R ligands across different chemical classes, but the quantitative differences in the interactions between the two aminoalkylindoles and rimonabant in the two discrimination groups suggest subtle variations in the ligand–receptor activation(s).
High affinity electrophilic and photoactivatable covalent endocannabinoid probes for the CB1 receptor.
- Chen Li, Wei Xu, S. Vadivel, P. Fan, A. Makriyannis
- Chemistry, BiologyJournal of Medicinal Chemistry
- 6 October 2005
The first two high affinity covalent anandamide probes for the CB1 receptor are designed and synthesized by introducing either an electrophilic isothiocyanato or a photoactivatable azido group at the terminal carbon of the arachidonic acid moiety.
The cannabinoid receptor antagonist SR-141716 does not readily antagonize open-field effects induced by the cannabinoid receptor agonist (R)-methanandamide in rats
Discriminative stimulus functions in rats of AM1346, a high-affinity CB1R selective anandamide analog
Unlike mAEA, the surmountable antagonism between rimonabant and AM1346 showed that the structural features of AEA can be modified to produce novel ligands that reduce the dissociation between the discriminative stimulus and rate decreasing effects of CB1R agonists derived from an AEA template.
Discriminative stimulus effects in rats of SR-141716 (rimonabant), a cannabinoid CB1 receptor antagonist
- T. Järbe, M. Harris, Chen Li, Qian Liu, A. Makriyannis
- Biology, MedicinePsychopharmacology
- 27 May 2004
SR-141716 induces a discriminative stimulus complex in DTA that shows potential for further examination of cannabinoid receptor antagonism.
Discriminative stimulus effects of the cannabinoid CB1 receptor antagonist rimonabant in rats
Rimonabant induces a discriminative stimulus in DTA that continues to show potential for further examination of cannabinoid receptor antagonism and resulted in strong unconditioned effects.
Effects of AM1346, a high-affinity CB1 receptor selective anandamide analog, on open-field behavior in rats
- T. Järbe, N. DiPatrizio, Chen Li, A. Makriyannis
- Biology, ChemistryBehavioural Pharmacology
- 1 November 2007
The data indicate that the anandamide analog AM1346 may be more behaviorally similar to cannabinoids like Δ9-THC than to other an andamide-based molecules such as methanandamide, i.e. AM356.
17 β-estradiol ( E 2 ) in membranes : Orientation and dynamic properties
This data indicates that the polymethine-2-stearoyl-sn-glycero-3-phosphocholine complex is a good ligand for high-performance liquid chromatographyatography of Na6(CO3)(SO4)2, where Na2SO4 is the major mineral component of Na2CO3 and PSPC is the secondary substance.
HPLC Determination of Praeruptorin A, Bergenin and Quercetin in Purpose-made Cigarette and its Smoke
For investigating the rate of active substances in traditional Chinese medicines transferring into cigarette smoke, the active substances, praeruptorin A, bergenin and quercetin, in test cigarettes…