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STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells*
Interleukin-17 (IL-17)-producing helper T (TH) cells, named as THIL-17, TH17, or inflammatory TH (THi), have been recently identified as a novel effector lineage. However, how cytokine signalsExpand
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Bcl6 Mediates the Development of T Follicular Helper Cells
T Follicular Helper Cell Differentiation When B cells respond to an infection, they often require help from CD4+ T cells to mount a proper response. It is thought that a subset of CD4+ effector TExpand
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Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages.
After activation, CD4(+) helper T (Th) cells differentiate into distinct effector subsets. Although chemokine (C-X-C motif) receptor 5-expressing T follicular helper (Tfh) cells are important inExpand
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Critical regulation of early Th17 cell differentiation by interleukin-1 signaling.
T helper (Th) 17 cells have been recently discovered in both mouse and human. Here we show that interleukin-1 (IL-1) signaling on T cells is critically required for the early programming of Th17 cellExpand
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Regulation of inflammatory responses by IL-17F
Although interleukin (IL) 17 has been extensively characterized, the function of IL-17F, which has an expression pattern regulated similarly to IL-17, is poorly understood. We show that like IL-17,Expand
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IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC–activated Th2 memory cells
Interleukin (IL) 25 (IL-17E), a distinct member of the IL-17 cytokine family, plays important roles in evoking T helper type 2 (Th2) cell–mediated inflammation that features the infiltrations ofExpand
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ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity
The role of specialized follicular helper T (TFH) cells in the germinal center has become well recognized, but it is less clear how effector T cells govern the extrafollicular response, the dominantExpand
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Interleukin 25 promotes the initiation of proallergic type 2 responses
The molecular mechanisms underlying the initiation of innate and adaptive proallergic type 2 responses are not understood. Interleukin (IL) 25, a member of the IL-17 cytokine family, was recentlyExpand
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Act1 Adaptor Protein Is an Immediate and Essential Signaling Component of Interleukin-17 Receptor*
Interleukin (IL)-17, the founding member of the IL-17 cytokine family, is the hallmark of a novel subset of CD4+ T cells that is regulated by TGFβ, IL-6, and IL-23. IL-17 plays an important role inExpand
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T helper 17 cells promote cytotoxic T cell activation in tumor immunity.
Although T helper 17 (Th17) cells have been found in tumor tissues, their function in cancer immunity is unclear. We found that interleukin-17A (IL-17A)-deficient mice were more susceptible toExpand
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