Chen Dan

Luo Xue-Gang2
Tong Jian-Bin2
2Luo Xue-Gang
2Tong Jian-Bin
1Lei De-Liang
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In response to injury, synapse alteration may occur earlier than the changes in the cell body of neurons. Although retinal ganglion cell death and thinning of the inner part of retina were found after acute high intraocular pressure (HIOP), the structural and functional changes of synapses in the retina remain unknown. In the present study, we investigated(More)
To visualize completely rat retinal microvessels, the gelatin-ink perfusion condition was systematically optimized using von Willebrand factor (vWf) immunostaining as control. Whether the vessel showed by the new perfusion condition can be used for double label with neurons or glial cells in the same retina was also tested. Our results showed that infusing(More)
MicroRNAs (miRNAs) are short, endogenously expressed RNAs (∼21–22 nt) processed from stem-loop regions of longer RNA precursors by a Dicer-like enzyme (Jones-Rhoades et al., 2006). In plants, microRNAs play an essential role in regulating many fundamental molecular interactions , including plant growth, development and response to environmental stress(More)
Acetylcholinesterase is the enzyme that terminates neurotransmission by hydrolyzing the acetylcholine released by the motoneurons at the neuromuscular junctions. Although acetylcholinesterase has been studied for almost a century, the underlying relationship between exercise-induced fatigue and acetylcholinesterase activity at the synaptic cleft is not(More)
Target engagement is a critical factor for therapeutic efficacy. Assessment of compound binding to native target proteins in live cells is therefore highly desirable in all stages of drug discovery. We report here the first compound library screen based on biophysical measurements of intracellular target binding, exemplified by human thymidylate synthase(More)
We consider the problem of low rank approximation of binary matrices. Here we are given a d × n binary matrix A and a small integer k < d. The goal is to find two binary matrices U and V of sizes d × k and k × n respectively, so that the Frobenius norm of A − UV is minimized. There are two models of this problem, depending on the definition of the product(More)
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