Chen Chen

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Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2).

Chao Xu, Chuanbing Bian, +11 authors Jinrong Min
Proceedings of the National Academy of Sciences…
2010

The polycomb repressive complex 2 (PRC2) is the major methyltransferase for H3K27 methylation, a modification critical for maintaining repressed gene expression programs throughout development. It… (More)

Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi.

Chen Chen, Jing Jin, +8 authors Tony J. Pawson
Proceedings of the National Academy of Sciences…
2009

Tudor domains are protein modules that mediate protein-protein interactions, potentially by binding to methylated ligands. A group of germline specific single and multiTudor domain containing… (More)

Drosophila odorant receptors are novel seven transmembrane domain proteins that can signal independently of heterotrimeric G proteins.

Renee Smart, Aidan Kiely, +7 authors Coral G. Warr
Insect biochemistry and molecular biology
2008

Olfaction in Drosophila is mediated by a large family of membrane-bound odorant receptor proteins (Ors). In heterologous cells, we investigated whether the structural features and signalling… (More)

Dynamic O-glycosylation of nuclear and cytosolic proteins: further characterization of the nucleocytoplasmic beta-N-acetylglucosaminidase, O-GlcNAcase.

Lance Wells, Yuan Gao, +4 authors Gerald W. Hart
The Journal of biological chemistry
2002

beta-O-linked N-acetylglucosamine (O-GlcNAc) is an abundant and dynamic post-translational modification implicated in protein regulation that appears to be functionally more similar to… (More)

Joint Modeling for Chinese Event Extraction with Rich Linguistic Features

Chen Chen, Vincent Ng
COLING
2012

Compared to the amount of research that has been done on English event extraction, there exists relatively little work on Chinese event extraction. We seek to push the frontiers of supervised Chinese… (More)

Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain.

Ke Liu, Chen Chen, +8 authors Jinrong Min
Proceedings of the National Academy of Sciences…
2010

Arginine methylation modulates diverse cellular processes and represents a molecular signature of germ-line-specific Piwi family proteins. A subset of Tudor domains recognize arginine methylation… (More)

Chinese Zero Pronoun Resolution: Some Recent Advances

Chen Chen, Vincent Ng
EMNLP
2013

We extend Zhao and Ng's (2007) Chinese anaphoric zero pronoun resolver by (1) using a richer set of features and (2) exploiting the coreference links between zero pronouns during resolution. Results… (More)

Chinese Zero Pronoun Resolution with Deep Neural Networks

While unsupervised anaphoric zero pronoun (AZP) resolvers have recently been shown to rival their supervised counterparts in performance, it is relatively difficult to scale them up to reach the next… (More)

Deciphering arginine methylation: Tudor tells the tale

Chen Chen, Timothy J Nott, Jing Jin, Tony J. Pawson
Nature Reviews Molecular Cell Biology
2011

Proteins can be modified by post-translational modifications such as phosphorylation, methylation, acetylation and ubiquitylation, creating binding sites for specific protein domains. Methylation has… (More)

Ataxia and Paroxysmal Dyskinesia in Mice Lacking Axonally Transported FGF14

Qing Wang, Mark Bardgett, +8 authors David M Ornitz
Neuron
2002

Fibroblast growth factor 14 (FGF14) belongs to a distinct subclass of FGFs that is expressed in the developing and adult CNS. We disrupted the Fgf14 gene and introduced an Fgf14(N-beta-Gal) allele… (More)

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