Chen-Chang Shih

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Genotype I of Japanese encephalitis virus first appeared in Taiwan in 2008. Phylogenetic analysis of 37 viruses from pig farms in 2009-2010 classified these viruses into 2 unique subclusters of genotype I viruses and suggested multiple introductions and swift replacement of genotype III by genotype I virus in Taiwan.
BACKGROUND Genotype I (GI) Japanese encephalitis virus (JEV) that replaced GIII virus has become the dominant circulating virus in Asia. Currently, all registered live and inactivated JEV vaccines are derived from genotype III viruses. In Taiwan, the compulsory JEV vaccination policy recommends that children receives four doses of formalin-inactivated(More)
Several mutations in the gene of proline-rich transmembrane protein 2 (PRRT2) have been identified as the causes of paroxysmal kinesigenic dyskinesia (PKD). PRRT2 is a small gene that contains 4 exons and encodes a 340-aminoacid protein with 2 transmembrane domains. It is expressed predominantly in the brain. In the current study, we examined the whole(More)
The virulence of genotype I (GI) Japanese encephalitis virus (JEV) is under debate. We investigated differences in the virulence of GI and GIII JEV by calculating asymptomatic ratios based on serologic studies during GI- and GIII-JEV endemic periods. The results suggested equal virulence of GI and GIII JEV among humans.
X-linked adrenoleukodystrophy (X-ALD; MIM #300100) is a eurodegenerative metabolic disease due to mutations in the “ATPinding cassette, sub-family D (ALD), member 1” gene (ABCD1) t Xq28 [1]. Adrenoleukodystrophy protein (ALDP), coded by the BCD1 gene, participates in the transport of cytosolic very long hain fatty acid (VLCFA) into the peroxisome for(More)
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