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Pyrrolidinyl peptide nucleic acid with α/β-peptide backbone
TLDR
A new conformationally constrained analog of PNA carrying an alternating α/β amino acid backbone consisting of (2'R,4'R)-nucleobase-subtituted proline and (1S,2S)-2-aminocyclopentanecarboxylic acid (acpcPNA) shows a hitherto unreported behavior, namely the inability to form self-pairing hybrids.
Convenient Procedure for Synthesis of N‐Protected β‐Aminomalonates and β‐Amino Acids From α‐Amidosulfones
Abstract A synthesis of N‐protected β‐aminomalonates starting from α‐amidosulfones under very mild and simple reaction conditions is described. Treatment of the sulfones with malonate esters in the