Chee-Guan Koh

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Therapeutic use of oligodeoxynucleotides (ODNs) that hybridize to and downregulate target mRNAs encoding proteins that contribute to malignant transformation has a sound rationale, but has had an overall limited clinical success in cancer due to insufficient intracellular delivery. Here we report a development of formulations capable of promoting targeted(More)
Two major concerns in the design and fabrication of microfluidic biochips are protein binding on the channel surface and protein denaturing during device assembly. In this paper, we describe new methods to solve these problems. A "fishbone" microvalve design based on the concept of superhydrophobicity was developed to replace the capillary valve in(More)
Microfluidics is very important in the world of BioMEMS, particularly for lab-ona-chip devices. There are many unusual differences from conventional fluidics, such as the significance of surface forces, the high shear/extensional rate, the high heat transfer rate, the low Reynolds number, and the high Weissenberg number. In this study, aqueous solutions of(More)
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