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Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains
The crystal structure of human Sestrin2 is reported, and it is shown that hSesn2 is twofold pseudo-symmetric with two globular subdomains, which are structurally similar but functionally distinct from each other. Expand
Tetraethylammonium dichlorido[N,N′‐(o‐phenylene)bis(isoquinoline‐2‐carboxamidato)‐κ4N]cobaltate(III)
In the title compound, (C8H20N)[Co(C26H16N4O2)Cl2], the four N atoms of the N,N′-(o-phenyl­ene)bis­(isoquinoline-2-carboxamidate) (biqb2−) ligand form the equatorial plane of a distorted octa­hedralExpand
Anionic ligand effect on the nature of epoxidizing intermediates in iron porphyrin complex-catalyzed epoxidation reactions.
It is suggested that the dependence of the product ratios on the anionic ligands of iron(III) porphyrin catalysts is due to the involvement of different reactive species in olefin epoxidation reactions. Expand
Stereoselective alkane hydroxylations by metal salts and m-chloroperbenzoic acid
Abstract Simple metal (M=Mn, Fe, Co) perchlorates associated with m -chloroperbenzoic acid are able to conduct stereoselective alkane hydroxylations via a mechanism involving metal-based oxidants;Expand
Controlling self-assembly of zinc(II)-benzoate coordination complexes with 1,4-bis(4-pyridyl)ethane by varying solvent and ligand-to-metal ratio : Their catalytic activities
Abstract Four new coordination polymers formed by zinc-benzoate with the 1,2-bis(4-pyridyl)ethane (bpe) bridging ligand have been prepared and characterized. Zinc-benzoates can be rationally tuned toExpand
Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease.
It is demonstrated that a rational structure-based design strategy can generate a small molecule that can target and modulate multiple factors, providing a new tool to uncover and address AD complexity. Expand
A single schiff base molecule for recognizing multiple metal ions: A fluorescence sensor for Zn(II) and Al(III) and colorimetric sensor for Fe(II) and Fe(III)
Abstract A simple and easily synthesized fluorescent and colorimetric chemosensor 1 , based on juloidine-imidazole moieties as a binding and signaling unit, has been synthesized in a one-stepExpand
New Insights into the Mechanisms of O−O Bond Cleavage of Hydrogen Peroxide and tert-Alkyl Hydroperoxides by Iron(III) Porphyrin Complexes
The mechanisms of heterolytic versus homolytic O−O bond cleavage of H2O2, tert-butyl hydroperoxide (t-BuOOH), 2-methyl-1-phenyl-2-propyl hydroperoxide (MPPH), and m-chloroperoxybenzoic acid (m-CPBA)Expand
Participation of Two Distinct Hydroxylating Intermediates in Iron(III) Porphyrin Complex-Catalyzed Hydroxylation of Alkanes
We have obtained evidence that acylperoxo-iron(III) porphyrin complexes 1a are involved as reactive hydroxylating intermediates in the hydroxylation of alkanes by m-chloroperoxybenzoic acid (m-CPBA)Expand