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Intervening Sequences of Regularly Spaced Prokaryotic Repeats Derive from Foreign Genetic Elements
- F. Mojica, Chcsar Díez-Villaseñor, J. García-Martínez, E. Soria
- BiologyJournal of Molecular Evolution
- 1 February 2005
It is shown that CRISPR spacers derive from preexisting sequences, either chromosomal or within transmissible genetic elements such as bacteriophages and conjugative plasmids, implying a relationship betweenCRISPR and immunity against targeted DNA.