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Very long chain fatty acids (VLCFAs) are essential fatty acids with multiple functions, including ceramide synthesis. Although the components of the VLCFA biosynthetic machinery have been elucidated,… (More)
Christine Zimmermann,1 Aline Santos,2 Kenneth Gable,3 Sharon Epstein,2 Charulatha Gururaj,4 Pierre Chymkowitch,1 Dennis Pultz,5 Steven V. Rødkær,5 Lorena Clay,6 Magnar Bjørås,1 Yves Barral,6 Amy… (More)
Sphingolipids are structural components of membranes, and sphingolipid metabolites serve as signaling molecules. The first and rate-limiting step in sphingolipid synthesis is catalyzed by serine… (More)