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  • Windy Berkofsky-Fessler, Tri Quang Nguyen, +11 authors Holly Hilton
  • Biology, Medicine
  • Molecular cancer therapeutics
  • 2009 (First Publication: 1 September 2009)
  • A genomics-based approach to identify pharmacodynamic biomarkers was used for a cyclin-dependent kinase inhibitory drug. R547 is a potent cyclin-dependent kinase inhibitor with a potentContinue Reading
  • Mudit Kakar, Charu Kanwal, John R. Davis, Henan Li, Carol S Lim
  • Chemistry, Medicine
  • The AAPS Journal
  • 2006 (First Publication: 1 December 2006)
  • Steroid hormone receptors (SHRs), such as glucocorticoid receptors (GR) and progesterone receptors (PR), are shuttling proteins that undergo continuous nuclear import and export. Various mechanismsContinue Reading
  • Igor Mikaelian, Denise Coluccio, +9 authors Eric B. Wheeldon
  • Biology, Medicine
  • Toxicologic pathology
  • 2008 (First Publication: 1 February 2008)
  • Gene expression was evaluated in the myocardium of male Wistar rats after a single subcutaneous administration of 0.5 mg of isoproterenol, a β-adrenergic agonist that causes acute tachycardia withContinue Reading
  • Ingrid A. Mayer, Christian F Singer, +14 authors Carlos L. Arteaga
  • Medicine
  • 2017 (First Publication: 31 January 2017)
  • TPS633 Background: The PI3K/AKT/mTOR pathway is the most frequently activated signaling pathway in breast cancer (BC). PIK3CA-activating mutations are the most common genetic alteration observed inContinue Reading