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We propose a modulation scheme that is based on wideband time-varying chirp signals for use in frequency-hopped code division multiple-access systems. The scheme is designed such that each user is assigned unique modulating chirp signals that efficiently occupy the hop bandwidth for identification at the receiver. We explain how the chirp modulation reduces(More)
G protein-coupled receptors (GPCRs) are tightly regulated by multifunctional protein β-arrestins. Two isoforms of β-arrestin sharing more than 70% sequence identity and overall very similar 3D structures, β-arrestins 1 and 2, were originally expected to be functionally redundant. However, in recent years multiple lines of emerging evidence suggest they have(More)
End-stage heart failure patients are being supported with continuous flow left ventricular assist devices (CF-LVAD) in increasing numbers. The severe physiologic and pharmacologic derangements associated with end-stage heart failure therapies predispose these patients to delirium. During a delirious episode, a patient may inadvertently disconnect CF-LVAD(More)
An epidemiological survey of 1239 normal subjects without respiratory symptoms was undertaken in an urban locality of New Delhi in 1974. The subjects were divided into males aged under or over 22 and females under or over 17. Various statistical models were calculated to relate peak expiratory flow rate to the age, height, and weight of the subjects in each(More)
G protein-coupled receptors (GPCRs) are one of the key players in extracellular signal recognition and their subsequent communications with cellular signaling machinery. Crystallization and high-resolution structure determination of GPCRs has been one of the major advances in the area of GPCR biology over the last 7-8 years. There have primarily been three(More)
G Protein-coupled receptors (GPCRs) constitute the largest family of cell surface receptors and drug targets. GPCR signalling and desensitization is critically regulated by β-arrestins (βarr). GPCR-βarr interaction is biphasic where the phosphorylated carboxyl terminus of GPCRs docks to the N-domain of βarr first and then seven transmembrane core of the(More)
Standardization of allergens are achieved by in vitro and in vivo methods. Some of the allergens from Western countries are standardized using biological potency of the extracts but no attempt has been made till now to standardize any of the pollen extracts from India based on biological units. Therefore, we have attempted to standardize two important(More)
BACKGROUND Total immunoglobulin E (IgE) is an important indicator of allergic disorders. However, its role in allergic patients in India has not been evaluated in relation to atopic status for a reference range as compared with healthy subjects. OBJECTIVE The aim of the study was to establish serum IgE levels in a diseased group, study its relationship(More)