Charmaine Yvonne Brown

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Granulocyte colony-stimulating factor (G-CSF) mRNA contains two distinct types of cis-acting mRNA destabilizing elements in the 3'-untranslated region. In addition to several copies of the AU-rich element the G-CSF mRNA also contains a destabilizing region that includes several predicted stem-loop structures. We report here that the destabilizing activity(More)
The floor plate (FP) is a midline signaling center, known to direct ventral cell fates and axon guidance in the neural tube. The recent identification of midbrain FP as a source of dopaminergic neurons has renewed interest in its specification and organization, which remain poorly understood. In this study, we have examined the chick midbrain and spinal FP(More)
Dedication This is dedicated to my parents, Mark and Iris, who have loved and supported me through the ups and downs, and to my grandparents, Chet and Joyce, without whom I wouldn't be where I am today. The floorplate (FP) is located at the ventral midline of the developing neural tube, and is involved in patterning and specification of ventral and dorsal(More)
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