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The membrane properties of pars compacta neurons in the in vitro guinea-pig substantia nigra have been studied in the presence of sodium, calcium and potassium channel blockers. The following properties, which have already been described for dopamine-containing substantia nigra zona compacta neurons were observed: high and low threshold calcium spikes; a(More)
The effects of gamma-hydroxybutyrate have been studied on the membrane properties of pars compacta neurons within the guinea-pig substantia nigra maintained in vitro. The effects of gamma-hydroxybutyrate are to (i) lower input resistance, (ii) hyperpolarize the cell membrane in a dose-dependent manner and (iii) facilitate calcium conductances. These effects(More)
Evidence is accumulating that a soluble, secretory form of acetylcholinesterase may have novel, non-cholinergic functions in certain brain regions, such as the substantia nigra. In this study, application of human recombinant acetylcholinesterase (rhAChE) to pars compacta neurons in the rostral substantia nigra resulted in a sustained hyperpolarization that(More)
In the nigrostriatal pathway, dopamine is released not only from striatal nerve terminals, but also locally from the dendrites of nigrostriatal neurones within the substantia nigra itself. Exogenous dopamine is known to inhibit the firing of these neurones when applied directly to the substantia nigra in micromolar concentrations: but the amounts used are(More)
In the substantia nigra, acetylcholinesterase may have a non-classical function unrelated to cholinergic transmission. Acetylcholinesterase is released from the dendrites of dopamine-containing nigrostriatal neurons and has a subsequent action on these cells, independent of hydrolysis of acetylcholine. The aim of this study was to explore further the(More)
Within the substantia nigra acetylcholinesterase has non-cholinergic actions that can be demonstrated at both behavioural and cellular levels: the aim of this study was, thus, to explore, in the in vitro guinea pig substantia nigra, the ionic mechanisms which mediate these non-classical phenomena. Acetylcholinesterase had a reversible hyperpolarizing(More)