Charlotte E Bussey

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T hroughout the body, most arteries and veins with an internal diameter >100 μm are invested with a layer of peri-vascular adipose tissue (PVAT), which comprises adipocytes, inflammatory cells, and stem cells in phenotypic states that depend on the body mass of the individual and their premor-bid state. Known locations of PVAT include the coronaries, aorta,(More)
G protein-coupled receptor 119 (GPR119) is involved in regulating metabolic homoeostasis, with GPR119 agonists targeted for the treatment of type-2 diabetes and obesity. Using the endogenous agonist oleoylethanolamide and a number of small molecule synthetic agonists we have investigated the temporal dynamics of receptor signalling. Using both a dynamic(More)
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