Charlotta Grunewald

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OBJECTIVE To compare the antenatal detection rate of malformations in chromosomally normal fetuses between a strategy of offering one routine ultrasound examination at 12 gestational weeks (gws) and a strategy of offering one routine examination at 18 gws. DESIGN Randomised controlled trial. SETTING Multicentre trial including eight hospitals. (More)
BACKGROUND Numerous epidemiological studies found an increased risk of schizophrenia among persons exposed to various obstetric complications. The underlying mechanisms are unknown. OBJECTIVE To study specific risk factors, as well as sets of risk factors, representing 3 different etiologic mechanisms: (1) malnutrition during fetal life; (2) extreme(More)
OBJECTIVE The relationship between cerebral perfusion pressure (CPP) and cerebral blood flow is unclear in preeclampsia. Our objective was to clarify this issue by comparing normal pregnant women to those with mild and severe preeclampsia. STUDY DESIGN Patients with mild (n = 72) and severe (n = 120) preeclampsia underwent transcranial Doppler (TCD)(More)
BACKGROUND There are few longitudinal data currently available detailing the normal changes in maternal cerebral hemodynamics during human pregnancy. This lack of information limits the study of pregnancy-associated cerebrovascular adjustments and, in particular, preeclampsia, where the brain appears to be especially susceptible to ischemic and(More)
OBJECTIVES To determine the accuracy of established ultrasound dating formulae when used at 12-14 and 15-20 gestational weeks. METHODS A total of 363 singleton pregnancies conceived after in-vitro fertilization (IVF) and randomized to a dating scan at 12-14 or 15-20 gestational weeks were studied. 'True' gestational age was calculated on the basis of the(More)
Congenital high-airway obstruction syndrome (CHAOS) is due to rare malformations and has been reported previously in only few cases. If the diagnosis can be made prenatally, the ex utero intrapartum treatment (EXIT) procedure may be life-saving. A healthy 28-year old nulli-para was referred because of isolated ascites found at gestational week 16 during(More)
OBJECTIVE To describe possible causes of delivery-related severe asphyxia due to malpractice. DESIGN AND SETTING A nationwide descriptive study in Sweden. POPULATION All women asking for financial compensation because of suspected medical malpractice in connection with childbirth during 1990-2005. METHOD We included infants with a gestational age of(More)
The Cambridge Worry Scale (CWS) is an instrument including 16 items measuring women's major worries during pregnancy. The aim of the study was to test the scale, translated into Swedish, on pregnant women in Stockholm. We also wanted to explore whether these women were worried about any item not included in the scale. An additional aim was to study possible(More)
OBJECTIVE To increase our knowledge of the occurrence of substandard care during labour. DESIGN A population-based case-control study. SETTING Stockholm County. POPULATION Infants born in the period 2004-2006 in Stockholm County. METHODS Cases and controls were identified from the Swedish Medical Birth Register, had a gestational age of +/-33(More)
OBJECTIVE To compare the rate of prenatal diagnosis of heart malformations between two policies of screening for heart malformations. DESIGN Randomised controlled trial. SETTING Six university hospitals, two district general hospitals. SAMPLE A total of 39 572 unselected pregnancies randomised to either policy. METHODS The 12-week policy implied one(More)