Charlie Tannenbaum

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The antisecretory properties of Pepto-Bismol (PB) and its active ingredient, bismuth subsalicylate (BSS), were studied in ligated (rabbit and pig) and unligated (rat) intestinal-segment models. When PB was administered to segments before intestinal inoculation with heat-labile (LT) Escherichia coli or Vibrio cholerae enterotoxins, the inhibition of fluid(More)
Myeloid derived suppressor cells (MDSC, CD33+CD11b+ HLA-DR ) play a major role in tumor-mediated immune evasion and are composed of at least 3 subsets PMN (CD15+), monocytic (CD14+) and lineage-negative (CD15-CD14-), and each has been shown to be significantly increased in some human tumor types and to correlate with metastatic burden, clinical cancer stage(More)
The blockade of negative immune regulators such as CTLA-4 and PD1 continues to show encouraging results in patients with solid malignancies. The efficacy of these therapies could be further enhanced in a combinatorial setting that includes adoptive cell therapy (ACT), and thus it is important to clearly understand the relative impact that checkpoint(More)
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