Charlie A. Laughton

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AIMS Modulation of DNA base excision repair (BER) has the potential to enhance response to chemotherapy and improve outcomes in tumours such as melanoma and glioma. APE1, a critical protein in BER that processes potentially cytotoxic abasic sites (AP sites), is a promising new target in cancer. In the current study, we aimed to develop small molecule(More)
Allergens are proteins that elicit T helper lymphocyte type 2 (Th2) responses culminating in IgE antibody production and allergic disease. However, we have no answer to the fundamental question of why certain proteins are allergens, while others are not. We hypothesized that analysis of the surface of diverse allergens may reveal common structural features(More)
It is now well established that bacterial populations utilize cell-to-cell signaling (quorum-sensing, QS) to control the production of public goods and other co-operative behaviours. Evolutionary theory predicts that both the cost of signal production and the response to signals should incur fitness costs for producing cells. Although costs imposed by the(More)
(2005). "Adenosine contributes to mu-opioid synaptic inhibition in rat substantia gelatinosa in vitro. (2005). "The first de novo-designed antagonists of the human NK2 receptor. Ashcroft, A.E. (2005). "Recent developments in electrospray ionisation mass spectrometry: noncovalently bound protein complexes. (2005). "Engineering thermal stability in RNA phage(More)
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