Charles W. Schmidt

Learn More
THE aim o f th is s tudy w as to dete r m in e p h en otyp ic dif fe r e nces w h e n BCG in vades m acr op h age s. Bacilli p r ep ar ed fr o m th e s am e BCG p rim ary s e ed, but p r oduce d in dif fe r e nt cultur e m edia , w er e an alys ed w ith r es p ect to th e ability to s tim ulate m acr op h age s an d th e s usce ptibility to tr eatm en t w(More)
Karakitsos and coworkers, in this journal, reported further compelling evidence on the value of ultrasound in guiding internal jugular vein catheterization. In a large, prospective, randomized study of 900 patients, comparisons were made between patients in whom the procedure was performed using landmark-based techniques and those assigned to ultrasound(More)
Background: Skeletal muscle depletion is an important complication of chronic obstructive pulmonary disease (COPD) but little prospective data exists about the rate at which it occurs and the factors that promote its development. We therefore prospectively investigated the impact of disease severity, exacerbation frequency and treatment with corticosteroids(More)
F or decades, efforts to slow global warming have mostly aimed to limit heat-trapping emissions of carbon dioxide (CO 2). Now scientists are pointing to a different class of warming agents they say also must be targeted to keep global temperatures in check. Dubbed " short-lived climate forcings " (SLCFs), these other emissions— namely, black carbon(More)
XIAP up-regulation is associated with chemotherapy resistance. Phenoxodiol causes XIAP degradation and chemotherapy sensitization in ovarian cancer. Here we assessed XIAP expression in melanomas, using tissue microarrays containing 436 melanomas and 336 nevi by a novel method of automated, quantitative analysis (AQUA). We used S100 to define pixels as(More)