Charles W. Otto

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Advanced cardiovascular life support (ACLS) impacts multiple key links in the chain of survival that include interventions to prevent cardiac arrest, treat cardiac arrest, and improve outcomes of patients who achieve return of spontaneous circulation (ROSC) after cardiac arrest. ACLS interventions aimed at preventing cardiac arrest include airway(More)
Laurie J. Morrison, Co-Chair*; Charles D. Deakin, Co-Chair*; Peter T. Morley; Clifton W. Callaway; Richard E. Kerber; Steven L. Kronick; Eric J. Lavonas; Mark S. Link; Robert W. Neumar; Charles W. Otto; Michael Parr; Michael Shuster; Kjetil Sunde; Mary Ann Peberdy; Wanchun Tang; Terry L. Vanden Hoek; Bernd W. Böttiger; Saul Drajer; Swee Han Lim; Jerry P.(More)
BACKGROUND Prompt initiation of bystander cardiopulmonary resuscitation (CPR) improves survival. Basic life support with mouth-to-mouth ventilation and chest compressions is intimidating, difficult to remember, and difficult to perform. Chest compressions alone can be easily taught, easily remembered, easily performed, adequately taught by(More)
BACKGROUND The 2005 Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care changed the previous ventilations-to-chest-compression algorithm for bystander cardiopulmonary resuscitation (CPR) from 2 ventilations before each 15 chest compressions (2:15 CPR) to 30 chest compressions before 2 ventilations (30:2 CPR). It was acknowledged(More)
BACKGROUND Global left ventricular dysfunction after successful resuscitation is well documented and appears to be a major contributing factor in limiting long-term survival after initial recovery from out-of-hospital sudden cardiac death. Treatment of such postresuscitation myocardial dysfunction has not been examined previously. METHODS AND RESULTS(More)
BACKGROUND Mouth-to-mouth rescue breathing is a barrier to the performance of bystander cardiopulmonary resuscitation (CPR). We evaluated the need for assisted ventilation during simulated single-rescuer bystander CPR in a swine model of prehospital cardiac arrest. METHODS AND RESULTS Five minutes after ventricular fibrillation, swine were randomly(More)
OBJECTIVE To determine whether high-dose epinephrine administration during cardiopulmonary resuscitation (CPR) in a swine pediatric asphyxial cardiac arrest model improves outcome (i.e., resuscitation rate, survival rate, and neurologic function) compared with standard-dose epinephrine. DESIGN A randomized, blinded study. SETTING A large animal(More)
Factors that may influence energy requirements for ventricular defibrillation include the duration of fibrillation and the mode of resuscitation. The present study assesses the effect of these influences on the energy needed for defibrillation. Dogs were anesthetized, and arterial blood pressure and Lead II of the ECG were continuously recorded. Ventricular(More)
A variety of CPR techniques and devices may improve hemodynamics or short-term survival when used by well-trained providers in selected patients. All of these techniques and devices have the potential to delay chest compressions and defibrillation. In order to prevent delays and maximize efficiency, initial training, ongoing monitoring, and retraining(More)
The effectiveness of ongoing cardiopulmonary resuscitation efforts is difficult to evaluate. Recent studies suggest that carbon dioxide excretion may be a useful noninvasive indicator of resuscitation from cardiac arrest. A prospective clinical study was done to determine whether end-tidal carbon dioxide monitoring during cardiopulmonary resuscitation could(More)