Charles W. Hall

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Although the zebrafish is increasingly used as a model organism to study epilepsy, no standard electrophysiological technique for recording electrographic seizures in adult fish exists. The purpose of this paper is to introduce a readily implementable technique for recording pentylenetetrazole seizures in the adult zebrafish. We find that we can(More)
Neural stimulation can reduce the frequency of seizures in persons with epilepsy, but rates of seizure-free outcome are low. Vagus nerve stimulation prevents seizures by continuously activating noradrenergic projections from the brainstem to the cortex. Cortical norepinephrine then increases GABAergic transmission and increases seizure threshold. Another(More)
Epilepsy affects an estimated 60 million people worldwide. As many as 50% of people with epilepsy will continue to have seizures despite therapeutic dosages of appropriately selected antiepileptic drugs. Among proposed treatment modalities for persons with medication refractory epilepsy are implantable devices that rapidly detect and abort seizures.(More)
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