Charles W. Duval

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The bacillus of glanders may be so modified in virulence as to produce experimentally lesions differing widely in their histological features. The highly virulent culture causes primary necrosis and disintegration of the tissue followed by the invasion of the injured area by polymorphonuclear leucocytes. The bacilli of moderate virulence give rise to a(More)
The four cultures which form the basis of this communication were recovered from peculiar cases of primary cervical adenitis in man, three of which terminated fatally of disseminated acute miliary tuberculosis in four to six weeks. A careful comparative study shows that Culture II corresponds closely with the "human" and Culture IV with the "bovine" type of(More)
1. Bacillus malleiand its poison produce a variety of vascular lesions in the rabbit and the guinea pig. 2. The type of the lesion depends upon, (a) the virulence of the culture, (b) the sex of the animal and (c) the degree of acquired immunity. 3. The vascular changes of a proliferative and degenerative nature produced by the slow action of the glanders(More)
encouraged us to accept the proposals of the Commission , placed the facilities of the laboratory at our disposal, and has maintained a constant interest in the progress of the investigation. The physicians of the hospital's clinical services , both visiting staff and house physicians, have given us every assistance in procuring material. On the part of the(More)
The cutaneous reaction demonstrates that the culture lysate of Streptococcus scarlatinae is approximately ten time more potent in its toxic effect than is the culture filtrate since repeated and carefully controlled human skin tests show that 0.1 cc. of a 1:2000 dilution of lysate reacts equally as well as a similar dose of a 1:250 dilution of culture(More)
The epidemic of dengue fever which occurred in certain of the Southern States during the fall of 1922 and the winter of 1922-23 afforded us the opportunity for investigating the nature of the virus. The disease has received little attention from the standpoint of research since the human transmission experiments of Ashburn and Craig 1 demonstrated the(More)
1. The several standard cultures used in this study are indistinguishable -a conclusion previously reached and stated by Flexner. 2. The acute dysentery of the United States is due to a bacillus indistinguishable from that obtained from the epidemics of dysentery in several other parts of the world. 3. The sporadic and the institutional outbreaks of acute(More)
According to our present conception of pigment-producing cells melanotic tumors do not occur outside the skin, eye and central nervous system, except as metastatic growths. Pigmented tumors that arise in the internal organs are traced in almost every case to a primary growth in a situation where pigment cells normally exist. Most commonly the black moles of(More)
In the cultivation of Bacillus leprae the initial multiplication outside the body cannot be obtained unless amino-acids are present in the medium. The amino-acids are believed to be essential nutritives for the initial growth of the organisms. It has been demonstrated that the primary growth of the leprosy bacilli occurs only in the presence of the products(More)