Charles V. Rohlicek

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BACKGROUND Neurodevelopmental disabilities in children with congenital heart defects (CHDs) have been primarily attributed to intraoperative events without consideration of preoperative and postoperative factors. OBJECTIVE To describe the preoperative and postoperative neurodevelopmental status of newborns and infants with CHDs. STUDY DESIGN One hundred(More)
OBJECTIVE To describe developmental and functional outcomes of children with congenital heart defects (CHDs) at school entry after open heart surgery. STUDY DESIGN Infants with CHDs who underwent surgical repair in infancy were recruited and assessed prospectively for developmental progress. At 5 years of age (64.2 +/- 11.3 months), 94 subjects were(More)
Methylenetetrahydrofolate dehydrogenase)methenyltetrahydrofolate cyclohydrolase)formyltetrahydrofolate synthetase (MTHFD1) is a trifunctional enzyme that interconverts tetrahydrofolate (THF) derivatives for nucleotide synthesis. A common variant in MTHFD1, p.Arg653Gln (c.1958G>A), may increase the risk for neural tube defects (NTD). To examine the(More)
OBJECTIVES To determine the prevalence of persistent developmental impairments in children with congenital heart defects and to identify factors that enhance risk for an adverse outcome. STUDY DESIGN Eligible infants (n = 131) <2 years of age requiring open heart surgery were recruited prospectively. Subjects were assessed during surgery and again 12 to(More)
This article provides an overview of a longitudinal study on a cohort of 131 newborns and young infants with congenital heart defects who required open heart surgery. The rationale for the study design is provided as well as a summary of the procedures used to evaluate these children prior to surgery, at discharge after surgery, 12-18 months later, and at 5(More)
OBJECTIVES Increased survival in infants with complex congenital heart defects (CHDs) has resulted in greater focus on morbidity. This prospective study was conducted to investigate whether or not neuromotor impairments evident acutely persist long-term. STUDY DESIGN A total of 94 infants with CHD were reassessed at school entry (age 64.2 +/- 11.3 months)(More)
OBJECTIVE To document the natural history and surgical outcomes for discrete subaortic stenosis in children. DESIGN Retrospective review. SETTING Tertiary care paediatric cardiology centres. PATIENTS 92 children diagnosed between 1985 and 1998. MAIN OUTCOME MEASURES Echocardiographic left ventricular outflow gradient (echograd), and aortic(More)
OBJECTIVE To determine the effects of chronic hypoxemia neonatally on the cardiovascular response to acute hypoxemia in adulthood. METHODS Experiments were conducted on adult rats (82+/-2 days) which had been made chronically hypoxemic (hypobaric hypoxia equivalent to FiO(2)=0.14) during the first ten days of life but raised in room air (Neonatally(More)
UNLABELLED Controversy exists regarding the integrity of the nervous system in the newborn with a congenital heart defect who must undergo corrective or palliative open heart surgery. Neurodevelopmental sequelae have been primarily attributed to surgical procedures without standardized evaluation of the preoperative neurologic status. OBJECTIVE To(More)
Infants who survive open-heart surgery are at risk for developmental disability, which may impact on the well-being not only of the child, but also the family. The objective of our prospective study, therefore, was to determine the long-term health-related quality of life of children with congenital cardiac malformations following open-heart surgery, and to(More)