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Comparative Analysis of Proteome and Transcriptome Variation in Mouse
The relationships between the levels of transcripts and the levels of the proteins they encode have not been examined comprehensively in mammals, although previous work in plants and yeast suggest aExpand
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Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors
In developing inhibitors of the LIM kinases, the initial lead molecules combined potent target inhibition with potent cytotoxic activity. However, as subsequent compounds were evaluated, theExpand
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Systems genetics analysis of gene-by-environment interactions in human cells.
Gene by environment (GxE) interactions are clearly important in many human diseases, but they have proven to be difficult to study on a molecular level. We report genetic analysis of thousands ofExpand
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Gene set enrichment analysis.
Set enrichment analytical methods have become commonplace tools applied to the analysis and interpretation of biological data. Expand
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Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits.
Subcutaneous adipose tissue stores excess lipids and maintains energy balance. We performed expression quantitative trait locus (eQTL) analyses by using abdominal subcutaneous adipose tissue of 770Expand
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Construction of a reference gene association network from multiple profiling data: application to data analysis
We propose a non-parametric, rankbased methodology to transform profiling data into a gene network. Expand
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CRISPR-DAV: CRISPR NGS data analysis and visualization pipeline
We present CRISPR-DAV (CRISPR Data Analysis and Visualization) pipeline to analyze the CRISpr NGS data in a high throughput manner. Expand
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Expression Profile of Drug and Nutrient Absorption Related Genes in Madin-Darby Canine Kidney (MDCK) Cells Grown under Differentiation Conditions
The expression levels of genes involved in drug and nutrient absorption were evaluated in the Madin-Darby Canine Kidney (MDCK) in vitro drug absorption model. MDCK cells were grown on plasticExpand
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Colocalization of GWAS and eQTL signals at loci with multiple signals identifies additional candidate genes for body fat distribution.
Integration of genome-wide association study (GWAS) signals with expression quantitative trait loci (eQTL) studies enables identification of candidate genes. However, evaluating whether nearbyExpand
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Biochemical and transcriptional profiling to triage additional activities in a series of IGF-1R/IR inhibitors.
Therapeutic development of a targeted agent involves a series of decisions over additional activities that may be ignored, eliminated or pursued. This paper details the concurrent application of twoExpand
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