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The emergence of methicillin-resistant Staphylococcus aureus (MRSA) has created the need for better therapeutic options. In this study, five natural xanthones were extracted and purified from the fruit hull of Garcinia mangostana and their antimicrobial properties were investigated. α-Mangostin was identified as the most potent among them against(More)
This paper examines the effect of geographic and industrial diversification on firm value for a sample of over 20,000 firm-year observations of U.S. corporations from 1987-1993. We find the value of a firm with international operations is 2.2% higher than a comparable single-activity domestic firm, while the value of a multiactivity firm is 5.4% lower than(More)
Taking advantage of the cluster effect observed in multivalent peptides, this work describes antifungal activity and possible mechanism of action of tetravalent peptide (B4010) which carries 4 copies of the sequence RGRKVVRR through a branched lysine core. B4010 displayed better antifungal properties than natamycin and amphotericin B. The peptide retained(More)
This work describes how to tune the amphiphilic conformation of α-mangostin, a natural compound that contains a hydrophobic xanthone scaffold, to improve its antimicrobial activity and selectivity for Gram-positive bacteria. A series of xanthone derivatives was obtained by cationic modification of the free C3 and C6 hydroxyl groups of α-mangostin with amine(More)
Defensins are small (3-5 kDa) cysteine-rich cationic proteins found in both vertebrates and invertebrates constituting the front line of host innate immunity. Despite intensive research, bactericidal and cytotoxic mechanisms of defensins are still largely unknown. Moreover, we recently demonstrated that small peptides derived from defensins are even more(More)
In recent years, interest has grown in the antimicrobial properties of certain natural and non-natural peptides. The strategy of inserting a covalent branch point in a peptide can improve its antimicrobial properties while retaining host biocompatibility. However, little is known regarding possible structural transitions as the peptide moves on the access(More)
Course Objective: The goal of this course is for students to improve scientific presentation skills. Course Structure: Hallmarks of an effective scientific presentation will be discussed during the first two class periods. Over the course of the semester, each student will develop a presentation and abstract based on his or her research. This talk will(More)
The rise of Distributed Denial of Service (DDoS) attacks has posed a dire threat to cloud computing services in recent years. First, it is getting increasingly difficult to discriminate legitimate traffic from malicious traffic since both are legal at the application-protocol level. Second, DDoS attacks have tremendous impacts on virtual machine performance(More)
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