Charles T. Mosier

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Proteases are required for processing precursors into active neuropeptides that function as neurotransmitters for cell-cell communication. This study demonstrates the novel function of human cathepsin V protease for producing the neuropeptides enkephalin and neuropeptide Y (NPY). Cathepsin V is a human-specific cysteine protease gene. Findings here show(More)
and Reference List Abstract and Reference List With increases in maintenance, equipment, and labor costs, the need for an effective maintenance program is increasing. Previous research has shown that the use of preventive maintenance procedures may allow for a simpler and less expensive way of maintaining and operating equipment. Many studies have dealt(More)
This study investigates a number of operational issues associated with the control of microprocessor fabrication facilities, specifically expanding the domain of previous research to investigate the effects of lot size, test wafer proportion, and tool productivity on wafer fabrication performance. Response variables included cost and production performance(More)
Beta-amyloid (Aβ) peptides are secreted from neurons, resulting in extracellular accumulation of Aβ and neurodegeneration of Alzheimer's disease. Because neuronal secretion is fundamental for the release of neurotransmitters, this study assessed the hypothesis that Aβ undergoes co-release with neurotransmitters. Model neuronal-like chromaffin cells were(More)
BACKGROUND AND AIMS N-truncated pyroglutamate (pGlu)-amyloid-β [Aβ(3-40/42)] peptides are key components that promote Aβ peptide accumulation, leading to neurodegeneration and memory loss in Alzheimer's disease. Because Aβ deposition in the brain occurs in an activity-dependent manner, it is important to define the subcellular organelle for pGlu-Aβ(3-40/42)(More)
This study investigates a number of operational issues associated with the control of microprocessor fabrication facilities, specifically expanding the domain of previous research to investigate the effects of lot size, test wafer proportion, and tool productivity on wafer fabrication performance. Response variables included cost and production performance(More)
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