Charles Schmitt

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Inconsistencies in the preparation of histology slides make it difficult to perform quantitative analysis on their results. In this paper we provide two mechanisms for overcoming many of the known inconsistencies in the staining process, thereby bringing slides that were processed or stored under very different conditions into a common, normalized space to(More)
Comparative Effectiveness Research (CER) is designed to provide research evidence on the effectiveness and risks of different therapeutic options on the basis of data compiled from subpopulations of patients with similar medical conditions. Electronic Health Record (EHR) system contain large volumes of patient data that could be used for CER, but the data(More)
Genomics research presents technical, computational, and analytical challenges that are well recognized. Less recognized are the complex sociological, psychological, cultural, and political challenges that arise when genomics research takes place within a large, decentralized academic institution. In this paper, we describe a Service-Oriented Architecture(More)
—Genomic research involves a considerable amount of intensive computational and data management challenges including varying demand for computing resources, large data staging, management of complex workflows, and managing data and metadata across thousands of experiments and datasets. To address these challenges, researchers are typically forced to acquire(More)
The value of workflows to the scientific community spans over time and space. Not only results but also performance and resource consumption of a workflow need to be replayed over time and in varying environments. Achieving such repeatability in practice is challenging due to changes in software and infrastructure over time. In this work, we introduce a new(More)
Electronic medical records (EMR) can be used to identify cohorts of patients who are clinically comparable to an individual patient. In this paper, we describe an approach that applies visual analytics to EMR data to describe the clinical course for an individual patient, display outcomes for a comparable cohort stratified by treatment, and generate(More)