Charles S. Algert

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BACKGROUND Blood pressure (BP) level is a major determinant of cardiovascular morbidity and mortality in individuals with diabetes mellitus. Several guidelines recommend lower BP goals and specific drug classes for these patients. The overviews reported herein were performed to formally compare the effects on cardiovascular events and death of different(More)
OBJECTIVES To determine population-based rates and outcomes of hypertensive disorders in pregnancy. DESIGN Cross-sectional study using linked population databases. SETTING AND PARTICIPANTS All women, and their babies, discharged from hospital following birth in New South Wales, between 1 January 2000 and 31 December 2002. MAIN OUTCOME MEASURES Rates(More)
OBJECTIVES To evaluate the blood pressure-dependent and independent effects of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) on major cardiovascular events. METHODS Using data from 26 large-scale trials comparing an ACEI or an ARB with placebo or another drug class, meta-regression analyses were conducted in which(More)
BACKGROUND As maternal deaths become rare in many countries, severe maternal morbidity has been suggested as a better indicator of quality of care. OBJECTIVE To develop and validate an indicator for measuring major maternal morbidity in routinely collected population health datasets (PHDS). METHODS First, diagnoses and procedures that might indicate(More)
OBJECTIVE To assess the accuracy of hypertensive disorders of pregnancy reporting in birth and hospital discharge data compared with data abstracted from medical records. METHODS Data from a validation study of 1200 women provided the 'gold standard' for hypertension status. The validation data were linked to both hospital discharge and birth databases.(More)
BACKGROUND Despite widespread use of neonatal hospital discharge data, there are few published reports on the accuracy of population health data with neonatal diagnostic or procedure codes. The aim of this study was to assess the accuracy of using routinely collected hospital discharge data in identifying neonatal morbidity during the birth admission(More)
BACKGROUND Linking population health data to pathology data is a new approach for the evaluation of predictive tests that is potentially more efficient, feasible and efficacious than current methods. Studies evaluating the use of first trimester maternal serum levels as predictors of complications in pregnancy have mostly relied on resource intensive(More)
OBJECTIVE To examine seasonality of pregnancy hypertension rates, and whether they related to sunlight levels around conception. STUDY DESIGN Data were obtained for 424,732 singleton pregnancies conceived from 2001 through 2005 in Australia. We analyzed monthly rates of pregnancy hypertension and preeclampsia in relation to monthly solar radiation. (More)
BACKGROUND Anaesthesia guidelines recommend regional anaesthesia for most caesarean sections due to the risk of failed intubation and aspiration with general anaesthesia. However, general anaesthesia is considered to be safe for the foetus, based on limited evidence, and is still used for caesarean sections. METHODS Cohorts of caesarean sections by(More)
OBJECTIVE The objective of this study was to compare international trends in pre-eclampsia rates and in overall pregnancy hypertension rates (including gestational hypertension, pre-eclampsia and eclampsia). DESIGN Population data (from birth and/or hospital records) on all women giving birth were available from Australia (two states), Canada (Alberta),(More)